A chemical conjugate of the tick P0 peptide is efficacious againstAmblyomma mixtum
| Autor: | Alina Rodríguez-Mallon, Milagros Vargas, Yamil Bello Soto, Mario Pablo Estrada García, Carlos Montero Espinosa, Karen Rosales Perdomo, Pedro E. Encinosa Guzmán |
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| Rok vydání: | 2020 |
| Předmět: |
Ribosomal Proteins
Tick Microbiology Amblyomma Antigen parasitic diseases Animals Antigens Vaccines General Veterinary General Immunology and Microbiology biology fungi General Medicine biology.organism_classification Vaccine efficacy Tick Infestations Vaccination Chemical conjugate Hemocyanins biology.protein Rhipicephalus microplus Female Immunization Rabbits Peptides Keyhole limpet hemocyanin |
| Zdroj: | Transboundary and Emerging Diseases. 67:175-177 |
| ISSN: | 1865-1682 1865-1674 |
| Popis: | After Rhipicephalus microplus, the most important tick species affecting livestock industry in Cuba belong to the Amblyomma genus. There are few reports of effective vaccine antigens for these species. Recently, vaccination and challenge trials using a peptide from the P0 acidic ribosomal protein of R. microplus ticks (pP0) as antigen have shown an efficacy around 90% against tick species from the Rhipicephalus genus. Given the high degree of sequence conservation among tick species, pP0 could be an antigen of versatile use in anti-tick vaccine formulations. In this paper, seven rabbits were immunized with a chemical conjugate of pP0 to keyhole limpet haemocyanin. Rabbits were challenged with an average of 1,900 Amblyomma mixtum larvae from a Cuban tick strain. The average number of recovered fed larvae and the viability of larvae in the moulting process were significantly lower in vaccinated animals compared with the control group. The overall vaccine efficacy of the P0 peptide antigen is 54% according to the calculated parameters. |
| Databáze: | OpenAIRE |
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