Effect of Valproate on Human Cerebral Glucose Metabolism
| Autor: | William H. Theodore, Edward B. Bromfield, Marshall Balish, Deborah B. Leiderman |
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| Rok vydání: | 1991 |
| Předmět: |
Phenytoin
medicine.medical_specialty medicine.medical_treatment Deoxyglucose Epilepsy Fluorodeoxyglucose F18 Internal medicine medicine Humans Generalized epilepsy Valproic Acid Dose-Response Relationship Drug business.industry Brain Metabolism Carbamazepine medicine.disease Surgery Glucose Anticonvulsant Endocrinology Neurology Drug Therapy Combination lipids (amino acids peptides and proteins) Phenobarbital Neurology (clinical) business Tomography Emission-Computed medicine.drug |
| Zdroj: | Epilepsia. 32:417-422 |
| ISSN: | 0013-9580 |
| DOI: | 10.1111/j.1528-1157.1991.tb04671.x |
| Popis: | We studied the effects of valproate (VPA) on local cerebral glucose metabolism (LCMRglc) in eight patients with partial seizure disorders and two with primary generalized epilepsy. Each patient had two positron-emission tomography (PET) scans with 18F-2-deoxyglucose (FDG), with, and without, VPA (mean level 52 mg/dl, range 30-127 mg/dl). Patients continued carbamazepine (CBZ) for both scans: serum concentrations were not significantly changed by VPA (CBZ range 5.4-12 mg/dl). Seven patients had the "without-VPA" scan first. Mean interval between PET scans was 75 days. Global CMRglc was decreased by 22% by addition of VPA (7.2 +/- 1.8 mg/100 g/min without VPA, 5.6 +/- 1.1 g/min with VPA, p less than 0.05, corrected). Thirteen regions of interest (ROIs) were analyzed in each hemisphere in each PET scan. Metabolic rates were significantly lower in 15 of 26 ROIs with VPA (p less than 0.05, corrected). VPA depresses cerebral metabolism to a greater degree than do CBZ and phenytoin (PHT) but less than does phenobarbital (PB). The metabolic effect may be related to the mechanism of action and have neuropsychological implications. |
| Databáze: | OpenAIRE |
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