Drosophila Arl8 is a general positive regulator of lysosomal fusion events
| Autor: | Szabolcs Takáts, Sarolta Tóth, Tamás Csizmadia, Péter Lőrincz, Gábor Juhász, Attila Boda, Attila L. Kovács |
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| Rok vydání: | 2019 |
| Předmět: |
Endosome
Regulator Motility Membrane Fusion 03 medical and health sciences 0302 clinical medicine Lysosome medicine Animals Drosophila Proteins Small GTPase Molecular Biology 030304 developmental biology 0303 health sciences Salivary gland ADP-Ribosylation Factors Chemistry Vesicle Autophagy Autophagosomes Cell Biology Cell biology Protein Subunits Drosophila melanogaster medicine.anatomical_structure rab GTP-Binding Proteins Lysosomes 030217 neurology & neurosurgery |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:533-544 |
| ISSN: | 0167-4889 |
| Popis: | The small GTPase Arl8 is known to be involved in the periphery-directed motility of lysosomes. However, the overall importance of moving these vesicles is still poorly understood. Here we show that Drosophila Arl8 is required not only for the proper distribution of lysosomes, but also for autophagosome-lysosome fusion in starved fat cells, endosome-lysosome fusion in garland nephrocytes, and developmentally programmed secretory granule degradation (crinophagy) in salivary gland cells. Moreover, proper Arl8 localization to lysosomes depends on the shared subunits of the BLOC-1 and BORC complexes, which also promote autophagy and crinophagy. In conclusion, we demonstrate that Arl8 is responsible not only for positioning lysosomes but also acts as a general lysosomal fusion factor. |
| Databáze: | OpenAIRE |
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