The role of CK2 protein kinase in stress response of RAW 264.7 macrophages
Autor: | Olga V. Glushkova, Elena G Novoselova, E. E. Fesenko, Maxim O. Khrenov, Sergey M Lunin, T. V. Novoselova |
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Rok vydání: | 2015 |
Předmět: |
animal structures
General Immunology and Microbiology Receptor expression Macrophages NF-kappa B General Medicine Biology NFKB1 General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Cell biology Cell Line Toll-Like Receptor 4 Mice Electromagnetic Fields Stress Physiological TLR4 Animals ASK1 Casein kinase 2 Signal transduction General Agricultural and Biological Sciences Protein kinase A Casein Kinase II Signal Transduction |
Zdroj: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 464 |
ISSN: | 1608-3105 |
Popis: | The role of casein kinase 2 (CK2) in the activation of the key NF-κB signaling cascade and other signaling and stress proteins during stress induced by exposure to nonthermal low-intensity electromagnetic radiation has been investigated. The ability of CK2 to regulate the activation of the NF-κB signaling cascade and upregulate the proinflammatory cytokine production and TLR4 receptor expression has been demonstrated. The existence of an alternative signaling pathway for NF-κB cascade activation directly involving protein kinase CK2 has been demonstrated using inhibition analysis in cells stressed by microwave irradiation. |
Databáze: | OpenAIRE |
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