The role of CK2 protein kinase in stress response of RAW 264.7 macrophages

Autor: Olga V. Glushkova, Elena G Novoselova, E. E. Fesenko, Maxim O. Khrenov, Sergey M Lunin, T. V. Novoselova
Rok vydání: 2015
Předmět:
Zdroj: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 464
ISSN: 1608-3105
Popis: The role of casein kinase 2 (CK2) in the activation of the key NF-κB signaling cascade and other signaling and stress proteins during stress induced by exposure to nonthermal low-intensity electromagnetic radiation has been investigated. The ability of CK2 to regulate the activation of the NF-κB signaling cascade and upregulate the proinflammatory cytokine production and TLR4 receptor expression has been demonstrated. The existence of an alternative signaling pathway for NF-κB cascade activation directly involving protein kinase CK2 has been demonstrated using inhibition analysis in cells stressed by microwave irradiation.
Databáze: OpenAIRE
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