Spectrin’s chimeric E2/E3 enzymatic activity
| Autor: | Steven R Goodman, Warren E. Zimmer, Rachel D Petrofes Chapa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Gene isoform
Cell signaling Erythrocytes DNA Repair biology DNA repair Multiple Organ Failure Ubiquitin-Protein Ligases Ubiquitination Spectrin EPB41 Minireviews Anemia Sickle Cell General Biochemistry Genetics and Molecular Biology Protein ubiquitination Cell biology Ubiquitin Biochemistry biology.protein Animals Humans Signal transduction Signal Transduction |
| Zdroj: | Experimental Biology and Medicine. 240:1039-1049 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | In this minireview, we cover the discovery of the human erythrocyte α spectrin E2/E3 ubiquitin conjugating/ligating enzymatic activity and the specific cysteines involved. We then discuss the consequences when this activity is partially inhibited in sickle cell disease and the possibility that the same attenuation is occurring in multiple organ dysfunction syndrome. We finish by discussing the reasons for believing that nonerythroid α spectrin isoforms (I and II) also have this activity and the importance of testing this hypothesis. If correct, this would suggest that the nonerythroid spectrin isoforms play a major role in protein ubiquitination in all cell types. This would open new fields in experimental biology focused on uncovering the impact that this enzymatic activity has upon protein–protein interactions, protein turnover, cellular signaling, and many other functions impacted by spectrin, including DNA repair. |
| Databáze: | OpenAIRE |
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