| Autor: |
Mei-Yi Liao, Tzu-Chi Huang, Yu-Cheng Chin, Ting-Yu Cheng, Geng-Min Lin |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS applied bio materials. 5(6) |
| ISSN: |
2576-6422 |
| Popis: |
The facile and straightforward fabrication of NIR-responsive theranostic materials with high biocompatibility is still an unmet need for nanomedicine applications. Here, we used a natural photosensitizer, iron chlorophyll (Chl/Fe), for the J-aggregate template-assisted synthesis of Au@Chl/Fe nanorods with high stability. The assembly of a high amount of Chl/Fe J-aggregate onto the Au surface enabled red-NIR fluorescence for monitoring and tracking residential tumor lesions. The Chl/Fe moieties condensed on the nanorods could change the redox balance by the photon induction of reactive oxygen species and attenuate iron-mediated lipid peroxidation by inducing a Fenton-like reaction. After conjugation with carboxyphenylboronic acid (CPBA) to target the glycoprotein receptor on T24 bladder cancer (BC) cells, the enhanced delivery of Au@Chl/Fe-CPBA nanorods could induce over 85% cell death at extremely low concentrations of 0.16 ppm |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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