Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia--a clinical research center study
| Autor: | Stephen F. Lowry, T van der Poll, S. M. Coyle, A. E. Barber |
|---|---|
| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Lipopolysaccharides Male medicine.medical_specialty Epinephrine Hydrocortisone medicine.medical_treatment Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Proinflammatory cytokine Endocrinology Internal medicine medicine Escherichia coli Humans Dose-Response Relationship Drug business.industry Tumor Necrosis Factor-alpha Biochemistry (medical) Endotoxemia Interleukin-10 Interleukin 10 Hypercortisolemia Cytokine Tumor necrosis factor alpha Female lipids (amino acids peptides and proteins) business Glucocorticoid medicine.drug |
| Zdroj: | Journal of clinical endocrinology and metabolism, 81(10), 3604-3606. The Endocrine Society |
| ISSN: | 0021-972X |
| DOI: | 10.1210/jc.81.10.3604 |
| Popis: | Hypercortisolemia directly before the administration of endotoxin (LPS) to normal humans completely prevents the release of the proinflammatory cytokine tumor necrosis factor, whereas hypercortisolemia 12 h to 7 days before the injection of LPS is associated with enhanced tumor necrosis factor release. To determine the effect of elevated cortisol levels on the secretion of the antiinflammatory cytokine interleukin-10 (IL-10), 23 healthy men were given iv LPS (lot EC-5; 2 ng/kg) alone or in combination with a continuous iv infusion of hydrocortisone (3 micrograms/kg.min) for 6 h immediately before or 6, 12, or 144 h before LPS injection. LPS induced a monophasic increase in plasma IL-10 concentrations that peaked after 2 h (162 +/- 27 pg/mL; P |
| Databáze: | OpenAIRE |
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