New 3-Dimensional Volumetric Ultrasound Method for Accurate Quantification of Atherosclerotic Plaque Volume
| Autor: | Beatriz López-Melgar, Virgina Mass, Paula Nogales, Javier Sánchez-González, Robert Entrekin, Antoine Collet-Billon, Xavier Rossello, Leticia Fernández-Friera, Antonio Fernández-Ortiz, Javier Sanz, Jacob F. Bentzon, Héctor Bueno, Borja Ibáñez, Valentín Fuster |
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| Přispěvatelé: | Ministerio de Economía, Industria y Competitividad (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Fundación ProCNIC, Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Carotid Artery Diseases
accuracy Swine Reproducibility of Results atherosclerotic plaque Atherosclerosis gold-standard Plaque Atherosclerotic plaque volume Carotid Arteries Imaging Three-Dimensional vascular ultrasound Predictive Value of Tests Animals Humans three-dimensional Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine Ultrasonography |
| Zdroj: | López-Melgar, B, Mass, V, Nogales, P, Sánchez-González, J, Entrekin, R, Collet-Billon, A, Rossello, X, Fernández-Friera, L, Fernández-Ortiz, A, Sanz, J, Bentzon, J F, Bueno, H, Ibáñez, B & Fuster, V 2022, ' New 3-Dimensional Volumetric Ultrasound Method for Accurate Quantification of Atherosclerotic Plaque Volume ', JACC: Cardiovascular Imaging, vol. 15, no. 6, pp. 1124-1135 . https://doi.org/10.1016/j.jcmg.2022.01.005 |
| Popis: | Carotid and femoral plaque burden is a recognized biomarker of cardiovascular disease risk. A new electronic-sweep 3-dimensional (3D)-matrix transducer method can improve the functionality and image quality of vascular ultrasound atherosclerosis imaging. This study aimed to validate this method for plaque volume measurement in early and intermediate-advanced plaques in the carotid and femoral territories. Plaque volumes were measured ex vivo in pig carotid and femoral artery specimens by 3-dimensional vascular ultrasound (3DVUS) using a 3D-matrix (electronic-sweep) transducer and its associated 3D plaque quantification software, and were compared with gold-standard histology. To test the clinical feasibility and accuracy of the 3D-matrix transducer, an experiment was conducted in intermediate-high risk individuals with carotid and femoral atherosclerosis. The results were compared with those obtained using the previously validated mechanical-sweep 3D transducer and established 2-dimensional (2D)-based plaque quantification software. In the ex vivo study, the authors assessed 19 atherosclerotic plaques (plaque volume, 0.76 µL-56.30 μL), finding strong agreement between measurements with the 3D-matrix transducer and the histological gold-standard (intraclass correlation coefficient [ICC]: 0.992; [95% CI: 0.978-0.997]). In the clinical analysis of 20 patients (mean age 74.6 ± 4.45 years; 40% men), the authors found 64 (36 carotid and 28 femoral) of 80 scanned territories with atherosclerosis (measured atherosclerotic volume, 10 μL-859 μL). There was strong agreement between measurements made from electronic-sweep and mechanical-sweep 3DVUS transducers (ICC: 0.997 [95% CI: 0.995-0.998]). Agreement was also high between plaque volumes estimated by the 2D and 3D plaque quantification software applications (ICC: 0.999 [95% CI: 0.998-0.999]). Analysis time was significantly shorter with the 3D plaque quantification software than with the 2D multislice approach with a mean time reduction of 46%. 3DVUS using new matrix transducer technology, together with improved 3D plaque quantification software, simplifies the accurate volume measurement of early (small) and intermediate-advanced plaques located in carotid and femoral arteries. This study was partially funded by grants from the Ministerio de Economia, Industria y Competividad (MEIC) with cofunding from the European Regional Development Fund (ERDF) (SAF2016-75580-R to Dr Bentzon) and (BES-2016-076633 to Dr Nogales). Research funding was also received from the Instituto de Salud Carlos III Spain (PIE16/ 00021 to Drs Bueno and Fuster). The CNIC is supported by the Min- isterio de Ciencia, Innovacion y Universidades (MICINN) and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). This study forms part of a Master Research Agreement between the CNIC and Philips Healthcare. Drs Sánchez- González, Entrekin, and Collet-Billon are employees of Philips Healthcare. All other authors have reported that they have no re- lationships to disclose related to the contents of this paper. Sí |
| Databáze: | OpenAIRE |
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