Calcium Supplementation Reduces Vertebral Bone Loss in Perimenopausal Women: A Controlled Trial in 248 Women between 46 and 55 Years of Age*
| Autor: | J. Coen Netelenbos, Petra J. M. Elders, Floris C. van Ginkel, Oscar R. Leeuwenkamp, Wil H. L. Hackeng, Paul Lips, Paul F. van der Stelt, Edwin Khoe |
|---|---|
| Přispěvatelé: | VU University medical center, Internal medicine |
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Bone disease Endocrinology Diabetes and Metabolism Osteocalcin Clinical Biochemistry Osteoporosis Elemental calcium chemistry.chemical_element Calcium Biochemistry Bone and Bones Excretion chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Osteoporosis Postmenopausal Creatinine Dose-Response Relationship Drug biology business.industry Incidence Biochemistry (medical) Middle Aged Alkaline Phosphatase Creatine medicine.disease Urinary calcium Hydroxyproline chemistry Food Fortified biology.protein Female business |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 73(3), 533-540. The Endocrine Society Elders, P J M, Netelenbos, J C, Lips, P, Ginkel, F C V, Khoe, E, Leeuwenkamp, O R, Hackeng, W H L & Stelt, P F V D 1991, ' Calcium supplementation reduces vertebral bone loss in perimenopausal women: A controlled trial in 248 women between 46 and 55 years of age ', Journal of Clinical Endocrinology and Metabolism, vol. 73, no. 3, pp. 533-540 . https://doi.org/10.1210/jcem-73-3-533 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | To study the effect of calcium supplementation on perimenopausal bone loss, 295 women were randomized into a control group and 2 supplementation groups receiving, respectively, 1000 and 2000 mg elemental calcium/day for a period of 2 yr. We observed a significant decrease in lumbar bone loss in relation to the calcium supplementation (mean loss after 2 yr of 3.5% in the control group vs. 1.3% and 0.7% in the 1000 and 2000 mg groups, respectively), a significant increase in urinary calcium excretion, and a significant decrease in the urinary hydroxyproline/creatinine ratio, serum alkaline phosphatase, osteocalcin, and 1, 25-dihydroxyvitamin D. The effect of calcium supplementation on lumbar bone loss was significant in the first year of supplementation, but not in the second. However, the urinary hydroxyproline/creatinine ratio and the serum alkaline phosphatase level remained significantly decreased in the treatment groups at the end of the study; this was not the case for serum osteocalcin. Calcium supplementation did not have a significant effect on metacarpal cortical bone loss. The difference in biochemical parameters between the 2 supplementation groups was small. No significant interaction was observed between the menopausal status of the subjects and the effect of calcium supplementation. We conclude that calcium supplementation retards lumbar bone loss in the first year of calcium supplementation by reducing bone turnover. However, the effect on lumbar bone loss over a longer time span is still uncertain. © 1991 by The Endocrine Society. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|