Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
| Autor: | Mochol, Gabriela, Kiryk, Anna, Filipkowski, Robert K., Wawrzyniak, Marcin, Lioudyno, Victoria, Knapska, Ewelina, Gorkiewicz, Tomasz, Balcerzyk, Marcin, Leski, Szymon, Van Leuven, Fred, Lipp, Hans-Peter, Wójcik, Daniel K., Kaczmarek, Leszek |
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| Přispěvatelé: | University of Zurich, Kaczmarek, L |
| Rok vydání: | 2011 |
| Předmět: |
Male
Genetically modified mouse 10017 Institute of Anatomy Transgene IntelliCage system Mice Transgenic 610 Medicine & health Water maze IntelliCage Mice Cognition Alzheimer Disease Amyloid precursor protein medicine Animals Humans Social behavior Circadian rhythm Cognitive deficit biology Individual learning Mice Inbred C57BL Disease Models Animal Ageing 2728 Neurology (clinical) Sensorimotor Neurology 2808 Neurology Group learning biology.protein 570 Life sciences Female Neurology (clinical) medicine.symptom Cognition Disorders Psychology Neuroscience |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname |
| ISSN: | 1567-2050 |
| DOI: | 10.2174/156720511798192745 |
| Popis: | In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model. This work was supported by MemStick grant (7 Frame-work Program of EU), the NCCR “Neural Plasticity and Re-pair” and Swiss National Science Foundation. |
| Databáze: | OpenAIRE |
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