Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems
| Autor: | Masayuki Nashimoto, Atsuko Shinohara, Minoru Suzuki, Yoshitaka Furuya, Minoru Ono, Ryouji Mizumachi, Novriana Dewi, Koji Ono, Shin-ichiro Masunaga, Yuuji Murata, Hiroyuki Takahashi, Hiroki Tanaka, Takumichi Sugihara, Haruo Yamauchi, Hironobu Yanagie, Yoshinori Sakurai, Hiroyuki Nakamura, Yasumasa Nonaka, Masashi Yanagawa, Yasuyuki Morishita, Jun Nakajima |
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| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Cancer Research chemistry.chemical_element Boron Neutron Capture Therapy Polyethylene glycol General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound PEG ratio medicine Animals Irradiation Boron Pharmacology Liposome Liver Neoplasms Radiochemistry technology industry and agriculture Cancer medicine.disease Neutron temperature Neutron capture chemistry Liposomes Rabbits Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| Popis: | Background/Aim: Tumor cell destruction by boron neutron capture therapy (BNCT) is attributed to the nuclear reaction between (10)B and thermal neutrons. The accumulation of (10)B atoms in tumor cells without affecting adjacent healthy cells is crucial for effective BNCT. We previously reported that several types of liposomal boron delivery systems (BDS) delivered effective numbers of boron atoms to cancer tissues, and showed tumor-growth suppression after thermal neutron irradiation. In the present study, we examined the effects of BNCT after intra-arterial infusion of (10)B-borono-dodecaborate ((10)BSH) by liposomal BDS in rabbit hepatic cancer models. Materials and Methods: We prepared (10)BSH-entrapped transferrin-conjugated polyethylene glycol liposomes constructed with distearoyl-boron lipid (TF-PEG-DSBL), and performed thermal neutron irradiation at the Kyoto University Institute for Integrated Radiation and Nuclear Science after intra-arterial infusion into rabbit VX-2 hepatic tumors. Results: Concentrations of (10)B in VX-2 tumors on delivery with TF-PEG-DSBL liposomes reached 25 ppm on day 3 after the injection. Tumor growth was suppressed by thermal neutron irradiation after intra-arterial injection of this (10)BSH-containing liposomal BDS, without damage to normal cells. Conclusion: The present results demonstrate the applicability of (10)B-containing TF-PEG-DSBL liposomes as a novel intra-arterial boron carrier in BNCT for cancer. |
| Databáze: | OpenAIRE |
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