Induction of experimental autoimmune thyroiditis by heat-denatured porcine thyroglobulin: a Tc1-mediated disease
| Autor: | Ferdinando Nicoletti, M. P. Brazillet, Orly Abehsira-Amar, Frédéric Batteux, Jeannine Charreire |
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| Rok vydání: | 1999 |
| Předmět: |
Cytotoxicity
Immunologic Protein Denaturation Hot Temperature Swine medicine.medical_treatment Immunology medicine.disease_cause Lymphocyte Activation Thyroglobulin Autoimmunity Autoimmune thyroiditis Interferon-gamma Mice Antigen Immunology and Allergy Medicine Cytotoxic T cell Animals RNA Messenger business.industry Thyroid Histocompatibility Antigens Class I Thyroiditis Autoimmune medicine.disease Immunoglobulin Isotypes CTL Disease Models Animal medicine.anatomical_structure Mice Inbred CBA Female business CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | European journal of immunology. 29(4) |
| ISSN: | 0014-2980 |
| Popis: | Recent studies have shown that denatured exogenous antigens can prime cytotoxic T lymphocytes (CTL). To assess the contribution of CTL to experimental autoimmune thyroiditis (EAT), porcine thyroglobulin (pTg) was heat-denatured (hdpTg) and injected i.v. into CBA/J mice, without the aid of adjuvants. Both lymphocytic infiltrations of the thyroid glands and levels of Tg-specific CTL were similar to those found in conventional EAT induced by Tg and adjuvants. In contrast, proliferative responses could not be detected, and titers of antibodies to pTg were 20 times lower. These EAT-inducer CTL belong to the CD8+ cell subset and exerted their thyroiditogenic potential through release of IFN-gamma. We conclude that hdpTg-induced EAT is mediated by type 1 cytotoxic T cells (Tc1). |
| Databáze: | OpenAIRE |
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