Photocurable platelet rich plasma bioadhesives

Autor: Terry W. J. Steele, Justin Yin Hao Lee, Nguan Soon Tan, Jun Kit Wang, Manisha Singh, Himansu Sekhar Nanda
Přispěvatelé: School of Materials Science and Engineering
Rok vydání: 2020
Předmět:
Zdroj: Acta Biomaterialia. 117:133-141
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2020.09.030
Popis: Closure of wounds with tissue adhesives has many advantages over sutures, but existing synthetic adhesives are toxic and have poor workability. Blood-derived adhesives display complete resorption but have adhesion too weak for reliable wound dressings. We propose a semi-synthetic design that combines the positive attributes of synthetic and blood-derived tissue adhesives. PAMAM-g-diazirine (PDz) is a rapidly gelling bioadhesive miscible in both aqueous and organic solvents. PDz blended with platelet-rich plasma (PRP) forms PDz/PRP composite, a semi-synthetic formulation that combines PDz’s wet tissue adhesion with PRP’s potent wound healing properties. Light-activated PDz/PRP bioadhesive composite has similar elasticity to soft tissues and behaves as an induced hemostat—an unmet clinical need for rapid wound dressings. PDz/PRP composite applied to in vivo full-thickness wounds observed a 25% reduction in inflammation, as assessed by the host-cell response. Ministry of Education (MOE) Accepted version The authors would like to thank the NTU Interdisciplinary Graduate School scholarship program and the School of Materials Science and Engineering for all the research facilities provided. The authors would like to acknowledge the financial support from the following grants: Ministry of Education Tier 2 Grant: Tailored soft tissue bioadhesives for site-specific therapy (MOE2012-T2-2-046); NTU-Northwestern Institute for Nanomedicine Grant: 3D-Printing of Electro-Curing Nanocomposite Living Electrodes for Cardiac Tissue Regeneration.
Databáze: OpenAIRE
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