GnRH agonist for final oocyte maturation in GnRH antagonist co-treated IVF/ICSI treatment cycles: Systematic review and meta-analysis
| Autor: | Mohamed Abdel-Ghafar Sayed Ahmed, Maged Elmohamady, M.A.F. Youssef, Hatem I. Abdelmoty |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Agonist
medicine.medical_specialty endocrine system medicine.drug_class Ovarian hyperstimulation syndrome Review Cochrane Library law.invention Andrology Randomized controlled trial law Internal medicine medicine GnRH antagonist General lcsh:Science (General) GnRH agonist ComputingMethodologies_COMPUTERGRAPHICS lcsh:R5-920 Multidisciplinary business.industry GnRH Antagonist HCG Ivf icsi medicine.disease Oocyte medicine.anatomical_structure Endocrinology Meta-analysis OHSS business lcsh:Medicine (General) hormones hormone substitutes and hormone antagonists lcsh:Q1-390 |
| Zdroj: | Journal of Advanced Research, Vol 6, Iss 3, Pp 341-349 (2015) Journal of Advanced Research |
| ISSN: | 2090-1224 2090-1232 |
| Popis: | Graphical abstract Final oocyte maturation in GnRH antagonist co-treated IVF/ICSI cycles can be triggered with HCG or a GnRH agonist. We conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy and safety of the final oocyte maturation trigger in GnRH antagonist co-treated cycles. Outcome measures were ongoing pregnancy rate (OPR) and ovarian hyperstimulation syndrome (OHSS) incidence. Searches: were conducted in MEDLINE, EMBASE, Science Direct, Cochrane Library, and databases of abstracts. There was a statistically significant difference against the GnRH agonist for OPR in fresh autologous cycles (n = 1024) with an odd ratio (OR) of 0.69 (95% CI: 0.52–0.93). In oocyte-donor cycles (n = 342) there was no evidence of a difference (OR: 0.91; 95% CI: 0.59–1.40). There was a statistically significant difference in favour of GnRH agonist regarding the incidence of OHSS in fresh autologous cycles (OR: 0.06; 95% CI: 0.01–0.33) and donor cycles respectively (OR: 0.06; 95% CI: 0.01–0.27). In conclusion GnRH agonist trigger for final oocyte maturation trigger in GnRH antagonist cycles is safer but less efficient than HCG. |
| Databáze: | OpenAIRE |
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