Cytokine Patterns in Brain Tumour Progression
| Autor: | Cristiana Tanase, Simona Mihai, Daniel Petrescu, Elena Codrici, Laura Necula, Mihaela Teodoru, Ionela Daniela Popescu, Radu Albulescu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Proteomics Article Subject medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay Inflammation Disease Biology Immune system Downregulation and upregulation Biomarkers Tumor lcsh:Pathology medicine Humans Aged Brain Neoplasms Gene Expression Profiling Cancer Immunosuppression Cell Biology Middle Aged Prognosis medicine.disease Gene Expression Regulation Neoplastic Cytokine Disease Progression Cytokines Female Tumor necrosis factor alpha medicine.symptom Glioblastoma Research Article lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2013 (2013) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1155/2013/979748 |
| Popis: | Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. Using new proteomic technology, we have investigated serum profile of pro- (IL-1β, IL-6, IL-8, IL-12, GM-CSF, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10), along with angiogenic factors (VEGF, bFGF) in order to assess tumoural aggressiveness. Our results indicate significant dysregulation in serum levels of cytokines and angiogenic factors, with over threefold upregulation of IL-6, IL-1β, TNF-α, and IL-10 and up to twofold upregulation of VEGF, FGF-2, IL-8, IL-2, and GM-CSF. These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain. |
| Databáze: | OpenAIRE |
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