Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1
| Autor: | James R. Davie, Geneviève P. Delcuve, Tasnim H. Beacon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Promoter General Medicine Biology Chromatin Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Gene expression Genetics Epigenetics Signal transduction Receptor Molecular Biology Gene hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Genome |
| ISSN: | 1480-3321 0831-2796 |
| DOI: | 10.1139/gen-2020-0124 |
| Popis: | The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney, and heart and detectable in a variety of tissues and cell types. Herein we review the chemical and mechanical signal transduction pathways regulating the expression of the ACE2 gene and the epigenetic/chromatin features of the expressed gene. |
| Databáze: | OpenAIRE |
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