Increased Leucocyte–Platelet Complex Formation in Recently Symptomatic versus Asymptomatic Carotid Stenosis Patients and in Micro-emboli Negative Subgroups
| Autor: | Bridget Egan, Justin A. Kinsella, Joseph Harbison, Dermot Cox, George Hamilton, Dominick J. H. McCabe, Prakash Madhavan, Sinéad M. Murphy, T. Coughlan, Stephen J.X. Murphy, Sean O’Neill, Niamh Moran, Mary Paula Colgan, Sean Tierney, Soon Tjin Lim, Desmond O'Neill, Richard A. Walsh, D. R. Collins, T. M. Feeley |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
Male 0301 basic medicine medicine.medical_specialty Cerebral arteries Cell Communication 030204 cardiovascular system & hematology Asymptomatic Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine Leukocytes Humans Medicine Carotid Stenosis Platelet Prospective Studies Platelet activation Stroke Aged business.industry Hematology Middle Aged Platelet Activation Prognosis medicine.disease Transcranial Doppler Stenosis 030104 developmental biology Intracranial Embolism Asymptomatic Diseases Disease Progression Cardiology Female medicine.symptom business |
| Zdroj: | Thrombosis and Haemostasis. 119:821-833 |
| ISSN: | 2567-689X 0340-6245 |
| Popis: | Introduction Cerebral micro-embolic signals (MES) predict risk of stroke in carotid stenosis patients. However, MES-negative ‘recently symptomatic patients’ also have a higher stroke risk than ‘asymptomatic patients’. Differences in platelet activation status may contribute to this disparity in risk. Methods This prospective, observational study assessed platelet biomarkers and their relationship with MES in asymptomatic versus symptomatic moderate (≥50–69%) or severe (≥70–99%) carotid stenosis patients. Full blood count parameters were measured and whole-blood flow cytometry was used to quantify platelet surface CD62P and CD63 expression and leucocyte–platelet complex formation. Bilateral simultaneous transcranial Doppler ultrasound of the middle cerebral arteries classified patients as ‘MES positive’ or ‘MES negative’. Results Data from 34 asymptomatic patients were compared with those from 43 symptomatic patients in the ‘early phase’ (≤ 4 weeks) and 37 of these symptomatic patients in the ‘late phase’ (≥ 3 months) after transient ischaemic attack/ischaemic stroke. There were no differences in %CD62P or %CD63 expression between early or late symptomatic and asymptomatic patients overall (p > 0.05). The percentage of lymphocyte–platelet complexes was higher in early symptomatic than in asymptomatic patients (2.8 vs. 2.16%; p Conclusion These data add to the evidence that leucocyte–platelet complex formation/platelet activation is increased in recently symptomatic versus asymptomatic patients, and may contribute to the pathogenesis of first and subsequent strokes in carotid stenosis patients, including those who are MES negative. |
| Databáze: | OpenAIRE |
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