A quantitative weight of evidence assessment of Hill's guidelines for causal inference for cosmetic talc as a cause of mesothelioma
| Autor: | Gary M. Marsh, Ania Urban, A. Michael Ierardi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Mesothelioma medicine.medical_specialty Time Factors Pleural Neoplasms Toxicology medicine.disease_cause Talc Risk Assessment Asbestos 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology Toxicity Tests Medicine Animals Humans Probability Pharmacology business.industry Guideline medicine.disease Causality Dermatology respiratory tract diseases 030104 developmental biology 030220 oncology & carcinogenesis Causal inference business Risk assessment medicine.drug |
| Zdroj: | Toxicology and applied pharmacology. 417 |
| ISSN: | 1096-0333 |
| Popis: | Cosmetic talc has been suggested to cause mesothelioma. To assess a potential causal relationship between cosmetic talc and mesothelioma, a quantitative weight of evidence analysis was performed in accordance with Hill's nine original guidelines for causal inference using a published empirical model to weight each respective guideline. Various epidemiological, toxicological, and exposure studies related to cosmetic talc and risk of mesothelioma were included in an evaluation of each of Hill's guidelines. Probabilities that the guidelines were true were assigned based on expert judgment. We applied a sensitivity analysis to evaluate the variability of our probability estimates. The overall probability of causality for cosmetic talc and mesothelioma was approximately 1.29% (range: 0.73%-3.96%). This low probability of causality supports the conclusion that cosmetic talc is not related to the development of mesothelioma. |
| Databáze: | OpenAIRE |
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