Nail changes in Langerhans cell histiocytosis: a possible marker of multisystem disease
| Autor: | Javier Mataix, Cristina Moscardó-Guilleme, María Pérez-Crespo, Isabel Betlloch, Ana Lucas-Costa |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Pathology Biopsy Dermatology Mastoid Langerhans cell histiocytosis Prednisone medicine Humans skin and connective tissue diseases integumentary system medicine.diagnostic_test business.industry Onycholysis Erythematous papule medicine.disease Histiocytosis Langerhans-Cell medicine.anatomical_structure Nails Child Preschool Pediatrics Perinatology and Child Health Nail (anatomy) Subungual hyperkeratosis Nail Changes Female business Tomography X-Ray Computed medicine.drug |
| Zdroj: | Pediatric dermatology. 25(2) |
| ISSN: | 1525-1470 |
| Popis: | We describe a child with a 6-month history of onycholysis, subungual hyperkeratosis, and hemorrhages in most of her fingernails and toenails. Nail involvement preceded the identification of osteolytic lesions at the mastoid on a cranial computed tomography scan, which was performed because of repeated episodes of acute otitis media. Some weeks later, a small number of erythematous papules developed over the trunk and face. The diagnosis of Langerhans cell histiocytosis was made by histopathologic examination of bone, skin, and bed and matrix nail biopsies. Response to treatment with vinblastine and prednisone was excellent. Nail changes in Langerhans cell histiocytosis are extremely uncommon, particularly as the presenting manifestation of the disease. The role of nail involvement as an unfavorable prognostic sign is unclear. |
| Databáze: | OpenAIRE |
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