Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats
| Autor: | Muhammed Etyemez, Tuba Aydin, Ahmet Uyar, Mehmet Güvenç, Nursel Dikmen, Cafer Tayer Işler, Mustafa Cellat |
|---|---|
| Přispěvatelé: | Belirlenecek |
| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Male Lipopolysaccharide Acute Lung Injury Iridoid Glucosides Immunology Anti-Inflammatory Agents Apoptosis Pharmacology Lung injury medicine.disease_cause Antioxidants Proinflammatory cytokine Mice chemistry.chemical_compound Olive leaf Oleuropein medicine Animals Immunology and Allergy lung injury Acute Respiratory-Distress Rats Wistar Lung Inflammation Modulation Tissue medicine.diagnostic_test business.industry Septic shock lipopolysaccharide respiratory system medicine.disease respiratory tract diseases Disease Models Animal Oxidative Stress Damage Bronchoalveolar lavage Neutrophil Infiltration chemistry oleuropein Cytokines Nf-Kappa-B In-Vivo Inflammation Mediators business Oxidative stress |
| Zdroj: | Inflammation. 44:2246-2259 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-021-01496-x |
| Popis: | Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI. Scientific Research Projects Coordination of Hatay Mustafa Kemal University [20] This study was financially supported by the Scientific Research Projects Coordination of Hatay Mustafa Kemal University (project number: 20.M.020). |
| Databáze: | OpenAIRE |
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