Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells
| Autor: | Mark C. Poznansky, Thierry Berney, Luhan Yang, Jon S. Odorico, Melanie L. Graham, Julia L. Greenstein, Lorenzo Piemonti, Bart O. Roep, Melissa K. Carpenter, Kevin A. D'Amour, Chad A. Cowan, Jose Oberholzer, C Ricordi, Alice A. Tomei, James F. Markmann, Ludovic Vallier, Albert Hwa, Dieter Egli, Giuseppe Orlando, Ali Naji, Michael R. Rickels, Giovanni Migliaccio, Shane T. Grey, Bernhard J. Hering, Thomas W.H. Kay, Dale L. Greiner, Ann Jensen Adams, Cristina Nostro, Barbara Ludwig, Qizhi Tang, Alireza Rezania, Daniel Pipeleers, Danwei Huangfu, Uri Ben-David, Douglas A. Melton, Daniel G. Anderson |
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| Přispěvatelé: | Pathology/molecular and cellular medicine, Vriendenkring VUB, Diabetes Pathology & Therapy, Odorico, Jon, Markmann, Jame, Melton, Dougla, Greenstein, Julia, Hwa, Albert, Nostro, Cristina, Rezania, Alireza, Oberholzer, Jose, Pipeleers, Daniel, Yang, Luhan, Cowan, Chad, Huangfu, Danwei, Egli, Dieter, Ben-David, Uri, Vallier, Ludovic, Grey, Shane T, Tang, Qizhi, Roep, Bart, Ricordi, Camilo, Naji, Ali, Orlando, Giuseppe, Anderson, Daniel G, Poznansky, Mark, Ludwig, Barbara, Tomei, Alice, Greiner, Dale L, Graham, Melanie, Carpenter, Melissa, Migliaccio, Giovanni, D'Amour, Kevin, Hering, Bernhard, Piemonti, Lorenzo, Berney, Thierry, Rickels, Mike, Kay, Thoma, Adams, Ann |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pancreas/cytology medicine.medical_treatment Cellular differentiation Islets of Langerhans Transplantation Regenerative Medicine Medical and Health Sciences Insulin-Secreting Cells/cytology Stem Cell Research - Nonembryonic - Human Insulin-Secreting Cells Induced pluripotent stem cell Gene Editing ddc:617 Pancreas Transplantation/methods Stem Cells Diabetes Immunosuppression Cell Differentiation Tissue Donors 3. Good health Stem Cell Research - Nonembryonic - Non-Human Pancreas Transplantation Development of treatments and therapeutic interventions Beta cell Stem cell Type 1 Pluripotent Stem Cells medicine.medical_specialty Stem Cell Transplantation/methods Pancreas transplantation Autoimmune Disease Article 03 medical and health sciences Diabetes mellitus Diabetes Mellitus medicine Immune Tolerance Animals Humans Muscle Skeletal Intensive care medicine Pancreas Metabolic and endocrine Transplantation 5.2 Cellular and gene therapies business.industry Pluripotent Stem Cells/cytology Congresses as Topic Stem Cell Research medicine.disease Diabetes Mellitus Type 1 030104 developmental biology Surgery Diabetes Mellitus Type 1/therapy business Stem Cell Transplantation Boston |
| Zdroj: | Transplantation Transplantation (2018) Transplantation, 102(8), 1223-1229 Transplantation, vol 102, iss 8 |
| ISSN: | 0041-1337 |
| Popis: | Beta cell replacement has the potential to restore euglycemia in patients with insulin dependent diabetes. While great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased donor organ supply cannot possibly treat all those who could benefit from restoration of a normal beta cell mass, especially if immunosuppression were not required. Against this background, the International Pancreas and Islet Transplant Association (IPITA) in collaboration with the Harvard Stem Cell Institute (HSCI), the Juvenile Diabetes Research Foundation (JDRF), and the Helmsley Foundation held a 2-day Key Opinion Leaders Meeting in Boston in 2016 to bring together experts in generating and transplanting beta cells derived from stem cells. The following summary highlights current technology, recent significant breakthroughs, unmet needs and roadblocks to stem-cell-derived beta cell therapies, with the aim of spurring future preclinical collaborative investigations and progress toward the clinical application of stem cell-derived beta cells. |
| Databáze: | OpenAIRE |
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