Histopathological and immunohistological analyses in IgA deficient lymphoplasia (aly/aly) mouse
| Autor: | Itaru Moro, Junichi Sato, Kazuo Komiyama, Masahiro Okaue, Toshiyuki Goto, Shinji Horimoto, Shigenori Akima, Tadamoto Akagi |
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| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty animal diseases Mice Inbred Strains Spleen Thymus Gland Biology Salivary Glands Mice Immune system Tongue medicine Animals IgG Deficiency Intestinal Mucosa Immunity Mucosal Lung Pancreas General Dentistry Immunodeficiency Submandibular lymph nodes Histocytochemistry IgA Deficiency respiratory system medicine.disease Immunohistochemistry Carbon Lymphocyte Subsets Mice Mutant Strains respiratory tract diseases Mice Inbred C57BL medicine.anatomical_structure Immunoglobulin M Liver Immunology biology.protein Female Lymph Nodes Antibody Peripheral lymph |
| Zdroj: | Journal of Oral Science. 43:91-96 |
| ISSN: | 1880-4926 1343-4934 |
| Popis: | The aly/aly mouse has a severe immunodeficiency, because it lacks peripheral lymph nodes as well as IgA and IgG immunoglobulin synthesis. In the present study, we performed histopathological and immunohistological examinations to clarify histological disorders of various immune organs in these mice. Carbon CH40 injections into the apex of the tongue confirmed the absence of submandibular lymph nodes in aly/aly mice. The thymus had a poorly constructed cortex and medulla, and the number of lymphoid follicles was clearly decreased in the spleen. No IgG-or IgA- producing cells were found in any immune organs, including the mucosal immune sites, though several IgM-producing cells were identified. Other characteristic findings included perivascular lymphocytes accumulation in the salivary glands, lungs, liver and pancreas, which caused tissues damage. These results demonstrated that the various lymphoid tissues disorders and organ-specific lymphocyte infiltration cause immuno-deficiency in the aly/aly mouse. (J. Oral Sci. 43, 91-96, 2001) |
| Databáze: | OpenAIRE |
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