Antihypertensive Effect of an Extract ofPassiflora edulisRind in Spontaneously Hypertensive Rats
| Autor: | Akiko Yamanaka, Susumu Maruyama, Toshiaki Ichimura, Tetsuya Toyokawa, Takako Tamamura, Yasuhiro Kamada, Toshio Ichiba |
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| Rok vydání: | 2006 |
| Předmět: |
Blood Pressure
Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry law.invention Passiflora chemistry.chemical_compound Spontaneously hypertensive rat Dry weight Liquid chromatography–mass spectrometry law Rats Inbred SHR Animals Food science Molecular Biology Antihypertensive Agents biology Plant Extracts Organic Chemistry General Medicine biology.organism_classification Rats chemistry Polyphenol Hypertension Plant Bark Phytotherapy Luteolin Quantitative analysis (chemistry) Chromatography Liquid Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 70:718-721 |
| ISSN: | 1347-6947 0916-8451 |
| Popis: | Orally administered methanol extract of Passiflora edulis rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 microg/g dry weight of luteolin and 41 microg/g dry weight of luteolin-6-C-glucoside. It also contained gamma-aminobutyric acid (GABA, 2.4 mg/g dry weight by LC-MS/MS or 4.4 mg/g dry weight by amino acid analysis) which has been reported to be an antihypertensive material. Since the extract contained a relatively high concentration of GABA, the antihypertensive effect of the extract in SHRs might be due mostly to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin. |
| Databáze: | OpenAIRE |
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