The International Normalized Ratio overestimates coagulopathy in stable trauma and surgical patients
Autor: | Martin A. Schreiber, Sean P. McCully, Thomas G. DeLoughery, Nicholas R. Kunio, Tahnee L. Groat, Katherine M. Watson, Loic Fabricant, Jerome A. Differding |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Critical Care and Intensive Care Medicine Young Adult Postoperative Complications Coagulopathy Humans Medicine International Normalized Ratio Prospective Studies Dosing Blood Coagulation Aged Aged 80 and over business.industry Blood Coagulation Disorders Middle Aged medicine.disease Thrombelastography Surgery Coagulation Wounds and Injuries Female Fresh frozen plasma business Follow-Up Studies Surgical patients |
Zdroj: | Journal of Trauma and Acute Care Surgery. 75:947-953 |
ISSN: | 2163-0755 |
DOI: | 10.1097/ta.0b013e3182a9676c |
Popis: | The international normalized ratio (INR) was developed to assess adequacy of Coumadin dosing. Its use has been generalized to guide fresh frozen plasma (FFP) therapy in stable patients. Thrombelastography (TEG) is a whole-blood assay measuring the viscoelastic properties of the clot in near real time. This study hypothesized that INR does not reflect coagulopathy and should not be used to guide FFP therapy in stable trauma and surgical patients.Prospective observational data were collected from stable trauma and surgical patients (n = 106) who received FFP transfusions. Pretransfusion and posttransfusion blood samples were obtained to assess complete blood count, standard coagulation parameters (INR, partial thromboplastin time, fibrinogen and D-dimer), soluble clotting factors (II, V, VII, VIII, IX, X, XI, XII, proteins C and S) and TEG. Data were analyzed using a Mann-Whitney U-test. Significance was defined as p0.05.A total of 262 U of FFP were transfused, with 78% of 106 patients receiving two or more units. Despite a reduction in INR, median TEG values remained within normal limits, while clotting factor levels retained adequate function to produce normal clotting before and following FFP transfusion.The use of FFP in this population did not affect coagulation status in a clinically relevant manner based on TEG values and coagulation factor function. INR is not a predictor of coagulopathy and should not be used to guide coagulation factor replacement in stable trauma and surgical patients.Diagnostic study, level III. |
Databáze: | OpenAIRE |
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