Effect of the Edible Mushroom Mycoleptodonoides aitchisonii on Transient Global Ischemia-Induced Monoamine Metabolism Changes in Rat Cerebral Cortex
| Autor: | Hidehiko Yokogoshi, Kyoko Tashiro, Nien Vinh Lam, Tamiko Hatakeyama, Satoshi Okuyama, Takehiko Terashima |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Metabolite Ischemia Medicine (miscellaneous) Brain Ischemia Brain ischemia chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Cerebral Cortex Biological Products Nutrition and Dietetics Dopaminergic Homovanillic acid Homovanillic Acid medicine.disease Rats Monoamine neurotransmitter medicine.anatomical_structure Endocrinology chemistry Ischemic Attack Transient Cerebral cortex Anesthesia Agaricales Carotid Artery Injuries Polyporales medicine.drug |
| Zdroj: | Journal of Medicinal Food. 15:96-99 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2011.1636 |
| Popis: | We performed a transient bilateral common carotid artery occlusion on rats and investigated whether feeding an aqueous extract of Mycoleptodonoides aitchisonii, an edible mushroom, affected metabolism of monoamines in the cerebral cortex, possibly protecting against ischemic damage. Seventeen days after the surgery, concentrations of the dopamine (DA) metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) and of homovanillic acid (HVA) in the cerebral cortex of the M. aitchisonii–fed group (MV) were higher than in the control ischemia (CV) group. The turnover rate of DA, which was indicated by (DOPAC+HVA)/DA, for the CV group was significantly lower than for the MV group, and the MV group value was the same rate as the sham-operated group. These data indicate that M. aitchisonii affects the dopaminergic neuronal system following brain ischemia damage in the cerebral cortex. |
| Databáze: | OpenAIRE |
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