First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans
| Autor: | Rosangela Do Socorro Ferreira Rodrigues Do Socorro Ferreira Rodrigues Sarquis, Maria de Fátima Vanderlei de Souza, Tiago Bezerra de Sá de Sousa Nogueira, Raimundo Braz Filho, Edeltrudes de Oliveira Lima, Davi Antas e Silva, Fillipe de Oliveira Pereira, Fernando Antônio de Medeiros, Milen Maria Magalhães de Souza Fernandes, Raquel Bezerra de Sá de Sousa Nogueira, Jéssica Karina da Silva Maciel, Josean Fechine Tavares |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Antifungal Agents
Magnetic Resonance Spectroscopy Cordia exaltata Molecular Conformation Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria Article Lignans Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound phytochemical study Cordia exaltata Lam Boraginaceae antimicrobial activity lcsh:Organic chemistry Gram-Negative Bacteria Drug Discovery Botany Physical and Theoretical Chemistry Candida Cordia Stigmasterol biology Plant Extracts Chemistry Organic Chemistry Plant Components Aerial Antimicrobial biology.organism_classification Anti-Bacterial Agents Phytochemical Chemistry (miscellaneous) Chemical constituents Molecular Medicine |
| Zdroj: | Molecules; Volume 18; Issue 9; Pages: 11086-11099 Molecules, Vol 18, Iss 9, Pp 11086-11099 (2013) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules180911086 |
| Popis: | The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-d-glucopyranoside (4a), stigmasterol-3-O-β-d-glucopyranoside (4b), phaeophytin A (5), 132-hydroxyphaeophytin A (6), 173-ethoxypheophorbide A (7), 132-hydroxy-173-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15), 5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4’-dimethoxyflavone (17), kaempherol 3-O-β-d-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-l-ramnopyranoside (19). Their structures were identified by 1H and 13C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time. |
| Databáze: | OpenAIRE |
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