The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India
| Autor: | Raman Preet, Kakarla V V Prasad, Preetha J Shetty, BR Rajeev |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Register based
Pediatrics medicine.medical_specialty lcsh:Surgery Blood Relative Consanguinity cleft lip 030230 surgery south india behavioral disciplines and activities 03 medical and health sciences consanguinity 0302 clinical medicine mental disorders Medicine 030212 general & internal medicine Craniofacial cleft palate business.industry Cleft lip South India Public Health Global Health Social Medicine and Epidemiology lcsh:RD1-811 lcsh:RK1-715 body regions Folkhälsovetenskap global hälsa socialmedicin och epidemiologi nervous system lcsh:Dentistry orofacial clefts Etiology business psychological phenomena and processes |
| Zdroj: | Journal of Cleft Lip Palate and Craniofacial Anomalies, Vol 4, Iss 1, Pp 3-8 (2017) |
| ISSN: | 2348-2125 |
| Popis: | Context: Orofacial cleft (OFC) is one of the common craniofacial malformations. The etiology of these OFCs is multifactorial. One of the etiological factors is consanguinity (marriage between blood relatives). There is a lack of literature reporting the number of people affected with OFCs due to consanguinity. Aims: The aim of this study is to report the occurrence of OFC and associated factors in relation to consanguinity from a craniofacial hospital specializing in OFCs, head and neck cancer, and trauma management in South India. Setting and Design: This was a hospital-based study, retrospective case record analysis. Methodology: One thousand two hundred and forty-seven consecutive patients' secondary data records with cleft lip (CL), cleft palate (CP) and cleft lip and palate (CL/P) were collected from January 2007 to July 2009. Statistics: Frequency of consanguinity in relation to OFC was analyzed using Chi-square test according to the nature of clefts and selected demographic features such as sex, region, and religion. Results: A total of 47.2% patients' parents had consanguineous marriage. Consanguinity was seen in 60.2% of male and 39.7% of female patients. CL/P was noticed in 40.9%, followed by CL (36.7%) and CP (22.2%). Males predominated in all types of clefts proportionally with the study population as compared to females. Statistically, significant association (P = 0.04) was seen with consanguinity and CP. Conclusion: Nearly half of the study population had a positive history of consanguinity. Statistically, a significant association was seen between CP and consanguinity. CL/P cases were the most common type identified, followed by CL and CP. Males predominated in all types of clefts. The prevalence of OFC is high, and there is a potential of congenital disabilities from consanguinity. These findings indicate a clear and urgent need for setting up a National Registry of Congenital Anomalies along with craniofacial defects, to monitor these trends and the corresponding need for supportive services. |
| Databáze: | OpenAIRE |
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