ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway
| Autor: | Qiaonan Guo, Jian-Xian Lin, Zhijun Huang, Hui-Yong Liu, F. Chen, Zhong-Yi Zhang, Qingzhi Yao, Jie Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cancer Research Asymmetric dimethylarginine Epithelial-Mesenchymal Transition Kaplan-Meier Estimate Adenocarcinoma Arginine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Movement Stomach Neoplasms Cell Line Tumor Medicine Humans Neoplasm Invasiveness Epithelial–mesenchymal transition Survival rate Wnt Signaling Pathway Survival analysis Cell Proliferation GC Wound Healing business.industry Wnt signaling pathway EMT Cancer General Medicine Middle Aged medicine.disease Prognosis ADMA 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Cancer cell Cancer research Female Signal transduction business Gastric cancer Research Article |
| Zdroj: | Clinical & Translational Oncology |
| ISSN: | 1699-3055 1699-048X |
| Popis: | Objective To explore the role of ADMA in gastric cancer. Methods The specimens of 115 gastric cancer patients were analyzed by ELISA and survival analysis. Functional assays were used to assess the effects of ADMA on gastric cancer cells. Experiments were conducted to detect the signaling pathway induced by ADMA in GC. Results Gastric cancer patients with high ADMA levels had poor prognosis and low survival rate. Furthermore, high level of ADMA did not affect the proliferation while promoted the migration and invasion of gastric cancer cell. Moreover, ADMA enhanced the epithelial–mesenchymal transition (EMT). Importantly, ADMA positively regulated β-catenin expression in GC and promoted GC migration and invasion via Wnt/β-catenin pathway. Conclusions ADMA regulates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway and which may be applied to clinical practice as a diagnostic and prognostic biomarker. |
| Databáze: | OpenAIRE |
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