Analgesic Activity of Methanol Leaf Extract of Tamarindus Indica Plant in Mice and Rats

Autor:	Highab, Salisu Muhammad, Raji, Ismaila, Abubakar, Abdulhakim, Hassan, Fatima Ismail
Rok vydání:	2022
Předmět:	Analgesic Fabaceae mice Tamarindus indica Wistar rats fungi food and beverages
Zdroj:	Dutse Journal of Pure and Applied Sciences; Vol. 7 No. 3b (2021); 143-154
ISSN:	2635-3490 2476-8316
DOI:	10.4314/dujopas.v7i3b.16
Popis:	Tamarindus indica has several folkloric uses in the treatment of various ailments. This study evaluated the analgesic activity of methanol leaf extract of Tamarindus indica (MLETI) in mice and Wistar rats. Acute toxicity studies were conducted using both the modified method of Lorke and OECD 425 guidelines. The analgesic activity was tested using acetic acid-induced writhing test, hot plate and formalin-induced hind-paw licking. Glycosides, flavonoids, saponins, alkaloids, reducing sugars, steroids and terpenoids were identified from the MLETI following phytochemical analysis. The LD50 was above 5000 mg/kg in both species. Compared to controls, the MLETI (50, 100, and 200 mg/kg) produced significant (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ed9412a224ecbbee37e408de187b1f https://doi.org/10.4314/dujopas.v7i3b.16 Zobrazit plný text záznamu