Systemic sclerosis and microscopic polyangiitis after systemic exposure to silicone

Autor: Claudia Carrera Muñoz, Annabel Abó Rivera, Jorge González Rodríguez, Jordi Roig Cárcel, Elena Estaran, Alfons Segarra Medrano
Přispěvatelé: Institut Català de la Salut, [Carrera Muñoz C, González Rodríguez J, Cárcel J] Department of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, Spain. [Abó Rivera A, Estarán E] Department of Pathological Anatomy, Hospital Universitari Arnau de Vilanova, Lleida, Spain. [Segarra Medrano A] Department of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, Spain. Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2021
Předmět:
Pathology
medicine.medical_specialty
Thrombotic microangiopathy
systemic sclerosis
silicon breast implants
Exceptional Cases
Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores]
medicine.disease_cause
Systemic scleroderma
Autoimmunity
chemistry.chemical_compound
compuestos inorgánicos::elementos::metaloides::silicio [COMPUESTOS QUÍMICOS Y DROGAS]
Silicone
Other subheadings::Other subheadings::/adverse effects [Other subheadings]
medicine
AcademicSubjects/MED00340
Transplantation
ASIA
Malalties autoimmunitàries
Silici - Efectes secundaris
Implants artificials
business.industry
Immune System Diseases::Autoimmune Diseases [DISEASES]
enfermedades del sistema inmune::enfermedades autoinmunes [ENFERMEDADES]
Cytoplasmic antibody
medicine.disease
thrombotic microangiopathy
crescentic glomerulonephritis
chemistry
Nephrology
Inorganic Chemicals::Elements::Metalloids::Silicon [CHEMICALS AND DRUGS]
Cohort
ANCA anti-MPO vasculitis
Microscopic polyangiitis
Vasculitis
business
Zdroj: Scientia
Clinical Kidney Journal
ISSN: 2048-8513
Popis: Glomerulonefritis creixent; Implants mamaris de silici; Esclerosi sistèmica Crescentic glomerulonephritis; Silicon breast implants; Systemic sclerosis Glomerulonefritis creciente; Implantes mamarios de silicio; Esclerosis sistémica The relationship between silicon breast implants (SBIs) and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been extensively analysed, with discordant results. We present a 45-year-old woman with confirmed systemic exposure to SBI who developed systemic sclerosis (SSc) followed by anti-neutrophil cytoplasmic antibody anti-myeloperoxidase vasculitis with renopulmonary syndrome. The novelty of our case is, first, confirmation of systemic exposure to SBI and, second, chronologic development of not one, but two severe autoimmune diseases. Controversy may still remain regarding SBIs and ASIA because it is unclear that previous studies confirmed systemic exposure to silicon in their cohort of patients. Grant number: PI18/00356 - Instituto de Salud Carlos III - FEDER "Una manera de hacer Europa" - CERCA Programme/Generalitat de Catalunya - IRBLleida - Fundació Dr. Pifarré
Databáze: OpenAIRE
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