Efficacy of Lyophilised Platelet-Rich Plasma Powder on Healing Rate in Patients With Deep Second Degree Burn Injury
| Autor: | Pai-Shan Hsieh, Li-Chuan Hsia, Lin-Gwei Wei, Keng-Yen Fu, Lien-Guo Dai, Niann-Tzyy Dai, Chi-Yung Yeung |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Body Surface Area Occlusive Dressings law.invention 030207 dermatology & venereal diseases 03 medical and health sciences Injury Severity Score 0302 clinical medicine Double-Blind Method Randomized controlled trial law Humans Medicine Platelet Prospective Studies Prospective cohort study Fibroblast Cell Proliferation Wound Healing Platelet-Rich Plasma business.industry Fibroblasts Prognosis Occlusive dressing Treatment Outcome 030104 developmental biology medicine.anatomical_structure Hemostasis Anesthesia Platelet-rich plasma Female Surgery Powders Burns business Wound healing |
| Zdroj: | Annals of Plastic Surgery. 80:S66-S69 |
| ISSN: | 0148-7043 |
| Popis: | Platelet-rich plasma (PRP) is a kind of plasma that is rich in platelets after processing. It includes various growth factors and cytokines, which speed up the process of wound healing and hemostasis. The PRP solution used in this study is diluted from lyophilized PRP powder, which decreased the possibility of contamination, facilitated the storage, and prolonged the storage life. From in vitro fibroblast proliferation testing, the numbers of PRP supplement were performed for 1, 4, and 7 times by continuous replacement of culture medium each day. Four times of lyophilized PRP supplement was selected for clinical study due to sufficient promotion of fibroblast proliferation. Next, 27 patients of deep second-degree burn wound were included in this study. Patients were assigned to two groups: PRP group (n = 15) and control group (n = 12). A concentration of 1.0 × 10 platelets/cm (wound area) according to wound size was sprayed on the wound evenly. Function was mainly assessed by the percentage of wound closure and bacteria picking out rate in 2 and 3 weeks. The wound closure at 3 weeks showed a significant difference in PRP group (P < 0.05). The healing rate of PRP group reached nearly 80% and made a breakthrough of 90% in 3 weeks, showing a significant difference compared with the control group (P < 0.05). Lyophilized PRP can be considered as an effective treatment to increase healing rate in patients with deep second-degree burn injury. |
| Databáze: | OpenAIRE |
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