The Effect of Transcranial Direct Current Stimulation in Changing Resting-State Functional Connectivity in Patients With Neurological Disorders: A Systematic Review
| Autor: | Mei Yan Chan, Yvonne M. Y. Han |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Functional impairment
medicine.medical_treatment resting-state functional connectivity neurological disorders Electroencephalography lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine medicine In patient lcsh:Neurology. Diseases of the nervous system 030304 developmental biology 0303 health sciences Transcranial direct-current stimulation medicine.diagnostic_test Resting state fMRI business.industry Functional connectivity functional magnetic resonance imaging Transcranial direct current stimulation Systematic Review business Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery electroencephalography |
| Zdroj: | Journal of Central Nervous System Disease Journal of Central Nervous System Disease, Vol 12 (2020) |
| ISSN: | 1179-5735 |
| Popis: | Background: People with neurological disorders are found to have abnormal resting-state functional connectivity (rsFC), which is associated with the persistent functional impairment found in these patients. Recently, transcranial direct current stimulation (tDCS) has been shown to improve rsFC, although the results are inconsistent. Objective: We hope to explore whether tDCS induces rsFC changes among patients with neurological disorders, whether rsFC is clinically relevant and how different tDCS parameters affect rsFC outcome among these individuals. Methods: A systematic review was conducted according to PRISMA guidelines (systematic review registration number: CRD42020168654). Randomized controlled trials that studied the tDCS effects on rsFC between the experimental and sham-controlled groups using either electrophysiological or neuroimaging methods were included. Results: Active tDCS can induce changes in both localized (ie, brain regions under the transcranial electrodes) and diffused (ie, brain regions not directly influenced by the transcranial electrodes) rsFC. Interestingly, fMRI studies showed that the default mode network was enhanced regardless of patients’ diagnoses, the stimulation paradigms used or the rsFC analytical methods employed. Second, stimulation intensity, but not total stimulation time, appeared to positively influence the effect of tDCS on rsFC. Limitations and conclusion: Due to the inherent heterogeneity in rsFC analytical methods and tDCS protocols, meta-analysis was not conducted. We recommend that future studies may investigate the effect of tDCS on rsFC for repeated cathodal stimulation. For clinicians, we suggest anodal stimulation at a higher stimulation intensity within the safety limit may maximize tDCS effects in modulating aberrant functional connectivity of patients with neurological disorders. |
| Databáze: | OpenAIRE |
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