Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective
| Autor: | Luiz S. Longo, Elaine G. Rodrigues, Arnold Stern, Ana Iochabel Soares Moretti, Adriana Karla Cardoso Amorim Reis, Paulo E da Costa, Mayte dos Santos Toledo, Hugo P. Monteiro, Fernando T. Ogata, Ana Caroline de Souza Teodoro |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Epithelial-Mesenchymal Transition Physiology Angiogenesis Clinical Biochemistry Breast Neoplasms 030204 cardiovascular system & hematology Nitric Oxide Biochemistry 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Tumor Microenvironment Mesenchymal–epithelial transition Animals Humans Nitric Oxide Donors Epithelial–mesenchymal transition Melanoma Tumor microenvironment Chemistry Cancer medicine.disease 030104 developmental biology Tumor progression Cancer cell Colonic Neoplasms Cancer research Reactive Oxygen Species Intracellular Signal Transduction |
| Zdroj: | Nitric oxide : biology and chemistry. 89 |
| ISSN: | 1089-8611 |
| Popis: | Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). However, intracellular interactions between NO and ROS must be controlled to prevent cell death. Melanoma, breast, and colon cancer cells have developed a mechanism to survive and adapt to oxidative and nitrosative stress. The mechanism involves a spatial-temporal fine adjustment of the intracellular concentrations of NO and ROS, thereby guaranteeing the successful development of cancer cells. Physiological concentrations of NO and supra physiological concentrations of ROS are prevalent in cancer cells at the primary site. The situation reverses in cancer cells undergoing the EMT prior to being released into the blood stream. Intracellular supra physiological concentrations of NO found in circulating cancer cells endow them with anoikis resistance. When the anoikis-resistant cancer cells arrive at a metastatic site they undergo the MET. Endogenous supra physiological concentrations of ROS and physiological NO concentrations are prevalent in these cells. Understanding tumor progression from the perspective of redox signaling permits the characterization of new markers and approaches to therapy. The synthesis and use of compounds with the capacity of modifying intracellular concentrations of NO and ROS may prove effective in disrupting a redox homeostasis operative in cancer cells. |
| Databáze: | OpenAIRE |
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