Association between genetic variants and esophageal cancer risk
| Autor: | Miao Li, Hongtao Meng, Xinhan Zhao, Chenli Yue, Chenxing Da, Shaomin Lv |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Risk 0301 basic medicine China medicine.medical_specialty Esophageal Neoplasms Genotype han chinese Single-nucleotide polymorphism Lower risk Polymorphism Single Nucleotide NAF1 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Internal medicine Biomarkers Tumor Odds Ratio medicine genetic polymorphism Humans Genetic Predisposition to Disease esophageal cancer Alleles Genetic Association Studies Aged Traditional medicine business.industry Genetic Variation Odds ratio Middle Aged Esophageal cancer medicine.disease Chinese people Confidence interval 030104 developmental biology Haplotypes Ribonucleoproteins Oncology Case-Control Studies 030220 oncology & carcinogenesis Female business case-control Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.17006 |
| Popis: | // Chenli Yue 1, 2, * , Miao Li 3, * , Chenxing Da 4 , Hongtao Meng 5 , Shaomin Lv 2 and Xinhan Zhao 1 1 Department of Internal Medicine Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China 2 Department of Respiratory Medicine, Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an, Shaanxi 710054, China 3 Department of Internal Medicine Oncology, The Fifth People’s Hospital of Qinghai Province, Xining, Qinghai 810007, China 4 Department of Gastroenterology, Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an, Shaanxi 710054, China 5 Medical Department, Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an, Shaanxi 710054, China * These authors have contributed equally to this work Correspondence to: Xinhan Zhao, email: zhaoxinhanprof@163.com Keywords: esophageal cancer, genetic polymorphism, NAF1, han chinese, case-control Received: October 27, 2016 Accepted: February 17, 2017 Published: April 10, 2017 ABSTRACT We investigated whether single nucleotide polymorphisms (SNPs) in the nuclear assembly factor 1 ( NAF1 ) and TNFAIP3-interacting protein 1 ( TNIP1 ) gene were associated with susceptibility to esophageal cancer in a Chinese Han population. Five SNPs were genotyped and their relationship with esophageal cancer risk was analyzed in a sample of 386 esophageal cancer patients and 495 unrelated healthy controls recruited from the First Affiliated Hospital of Xi’an Jiaotong University. Patients with the AG genotype of rs2320615 were at lower risk of developing esophageal cancer than those with the GG genotype (adjusted odds ratio [OR] = 0.64, 95% confidence interval [CI] = 0.46-0.90, P = 0.009). The rs2320615 SNP was found to be associated with a decreased the risk of esophageal cancer in the dominant model (adjusted OR = 0.70, 95% CI = 0.51-0.96, P = 0.026). These results provide the first evidence that the rs2320615 in NAF1 was associated with reduced risk of esophageal cancer. Further studies with larger samples are warranted to confirm our findings. |
| Databáze: | OpenAIRE |
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