Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta
| Autor: | Alan Leviton, Thomas M. O'Shea, Joseph A. Majzoub, Elizabeth N. Allred, Robert M. Joseph, Karl C.K. Kuban, Elgan Study Investigators |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
endocrine system medicine.drug_class Corticotropin-Releasing Hormone Placenta Physiology Child Behavior Article 03 medical and health sciences Corticotropin-releasing hormone 0302 clinical medicine Pregnancy medicine Humans Child Language Tests business.industry Extremely preterm Infant Newborn Wechsler Adult Intelligence Scale General Medicine 030227 psychiatry medicine.anatomical_structure Quartile Differential Ability Scales Neurodevelopmental Disorders Infant Extremely Premature Pediatrics Perinatology and Child Health Corticosteroid Female business 030217 neurology & neurosurgery Hormone |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 107(11) |
| ISSN: | 1651-2227 |
| Popis: | Aim To evaluate the relationship between corticotropin-releasing hormone (CRH) expression in the placenta and the risk of school-related dysfunctions at the age of 10 years among children born extremely preterm (EP). Methods Corticotropin-releasing hormone expression was measured in the placenta of 761 EP children, who had the following assessments at the age of 10 years: Differential Ability Scales, Oral and Written Language Scales, the Wechsler Individual Achievement Test-III, NEPSY-II and the Child Symptom Inventory-4. We evaluated whether lowest and highest quartiles of CRH mRNA were associated with undesirable scores on these assessments. With 272 evaluations, we would expect 14 to be significant at p Results Only 16 associations were statistically significant. On the other hand, seven of these were social limitations among girls whose placenta CRH mRNA was in the top quartile. Adjusting for delivery indication or restricting the sample to one delivery indication group resulted in few differences. Conclusion Overall, placenta CRH mRNA concentrations in the top or bottom quartiles were not associated with increased risks of dysfunctions 10 years later. Girls whose placenta CRH expression was in the top quartile, however, were at increased risk of seven indicators/correlates of social limitations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text