Highly Stretchable, Biocompatible, Striated Substrate Made from Fugitive Glue
| Autor: | Martin Guthold, Xinyi Guo, Tomas Lucioni, Amanda Smelser, Wei Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Materials science
stretchable lcsh:Technology Article law.invention credit card glue Optical microscope law Copolymer General Materials Science Composite material GLUE lcsh:Microscopy lcsh:QC120-168.85 styrenic block copolymer lcsh:QH201-278.5 lcsh:T fungi fugitive glue Substrate (chemistry) food and beverages fibrin fibers biocompatible substrate Biocompatible material 3. Good health human mammary epithelial cells lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics Adhesive lcsh:Electrical engineering. Electronics. Nuclear engineering transparent lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 |
| Zdroj: | Materials, Vol 8, Iss 6, Pp 3508-3518 (2015) Materials Volume 8 Issue 6 Pages 3508-3518 |
| ISSN: | 1996-1944 |
| Popis: | We developed a novel substrate made from fugitive glue (styrenic block copolymer) that can be used to analyze the effects of large strains on biological samples. The substrate has the following attributes: (1) It is easy to make from inexpensive components (2) It is transparent and can be used in optical microscopy (3) It is extremely stretchable as it can be stretched up to 700% strain (4) It can be micro-molded, for example we created micro-ridges that are 6 μm high and 13 μm wide (5) It is adhesive to biological fibers (we tested fibrin fibers), and can be used to uniformly stretch those fibers (6) It is non-toxic to cells (we tested human mammary epithelial cells) (7) It can tolerate various salt concentrations up to 5 M NaCl and low (pH 0) and high (pH 14) pH values. Stretching of this extraordinary stretchable substrate is relatively uniform and thus, can be used to test multiple cells or fibers in parallel under the same conditions. |
| Databáze: | OpenAIRE |
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