First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain

Autor: Paloma Guelbenzu, Jordi Camps, Carolina Lozano, Wojciech Rojewski, Alba Català, Mireia Feliu, Esther Roquer-Fanlo, Antoni Rabassa, Natàlia Andreychuk, Josep Colom, Gabriel de Febrer, Laia Revuelta, Jorge Joven, Èric Castañé, Anna Hernández-Aguilera, Noèlia Sabaté, Xavier Gabaldó, Neus Rius-Gordillo, Elisabet Rodríguez-Tomàs, Ana F. López-Azcona, Anna Teixidó, Pedro Pardo, Antoni Castro, Gerard Baiges-Gaya, Isabel Pujol, Joan Gil, Pedro Garrido, Salvador Hernández-Flix, Simona Iftimie, Frederic Ballester, Francesc Riu, Diana Garrido, Carlos Vasco, Immaculada Vallverdú, Marta Ríos, José Burdeos, Francesc Marimon, Helena Castañé, Marc Benavent, Sandra Parra
Rok vydání: 2021
Předmět:
RNA viruses
Male
Viral Diseases
Pediatrics
Critical Care and Emergency Medicine
Pulmonology
Coronaviruses
Anticoagulant Therapy
medicine.medical_treatment
Fevers
Comorbidity
Disease
Type 2 diabetes
Cardiovascular Medicine
030204 cardiovascular system & hematology
Medical Conditions
0302 clinical medicine
Oxygen therapy
Epidemiology
Case fatality rate
Medicine and Health Sciences
030212 general & internal medicine
Acute Respiratory Distress Syndrome
Pathology and laboratory medicine
Virus Testing
Multidisciplinary
Pharmaceutics
Medical microbiology
Middle Aged
Hospitalization
Cardiovascular Therapy
Infectious Diseases
Treatment Outcome
Cardiovascular Diseases
Viruses
Medicine
Female
SARS CoV 2
Pathogens
Research Article
medicine.medical_specialty
SARS coronavirus
Science
Cardiology
Microbiology
Respiratory Disorders
03 medical and health sciences
Signs and Symptoms
Drug Therapy
Respiratory Failure
Diagnostic Medicine
medicine
Humans
Pandemics
Aged
Mechanical ventilation
Biology and life sciences
business.industry
Organisms
Viral pathogens
COVID-19
Covid 19
medicine.disease
Microbial pathogens
Pneumonia
Dyspnea
Spain
Clinical Medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248029 (2021)
ISSN: 1932-6203
Popis: Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during spring followed by the current second wave in late summer and autumn. Empirical data show that the characteristics of the effects of the virus do vary between the two periods. Differences in age range and severity of the disease have been reported, although the comparative characteristics of the two waves still remain largely unknown. Those characteristics are compared in this study using data from two equal periods of 3 and a half months. The first period, between 15th March and 30th June, corresponding to the entire first wave, and the second, between 1st July and 15th October, corresponding to part of the second wave, still present at the time of writing this article. Two hundred and four patients were hospitalized during the first period, and 264 during the second period. Patients in the second wave were younger and the duration of hospitalization and case fatality rate were lower than those in the first wave. In the second wave, there were more children, and pregnant and post-partum women. The most frequent signs and symptoms in both waves were fever, dyspnea, pneumonia, and cough, and the most relevant comorbidities were cardiovascular diseases, type 2 diabetes mellitus, and chronic neurological diseases. Patients from the second wave more frequently presented renal and gastrointestinal symptoms, were more often treated with non-invasive mechanical ventilation and corticoids, and less often with invasive mechanical ventilation, conventional oxygen therapy and anticoagulants. Several differences in mortality risk factors were also observed. These results might help to understand the characteristics of the second wave and the behaviour and danger of SARS-CoV-2 in the Mediterranean area and in Western Europe. Further studies are needed to confirm our findings.
Databáze: OpenAIRE
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