First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain
Autor: | Paloma Guelbenzu, Jordi Camps, Carolina Lozano, Wojciech Rojewski, Alba Català, Mireia Feliu, Esther Roquer-Fanlo, Antoni Rabassa, Natàlia Andreychuk, Josep Colom, Gabriel de Febrer, Laia Revuelta, Jorge Joven, Èric Castañé, Anna Hernández-Aguilera, Noèlia Sabaté, Xavier Gabaldó, Neus Rius-Gordillo, Elisabet Rodríguez-Tomàs, Ana F. López-Azcona, Anna Teixidó, Pedro Pardo, Antoni Castro, Gerard Baiges-Gaya, Isabel Pujol, Joan Gil, Pedro Garrido, Salvador Hernández-Flix, Simona Iftimie, Frederic Ballester, Francesc Riu, Diana Garrido, Carlos Vasco, Immaculada Vallverdú, Marta Ríos, José Burdeos, Francesc Marimon, Helena Castañé, Marc Benavent, Sandra Parra |
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Rok vydání: | 2021 |
Předmět: |
RNA viruses
Male Viral Diseases Pediatrics Critical Care and Emergency Medicine Pulmonology Coronaviruses Anticoagulant Therapy medicine.medical_treatment Fevers Comorbidity Disease Type 2 diabetes Cardiovascular Medicine 030204 cardiovascular system & hematology Medical Conditions 0302 clinical medicine Oxygen therapy Epidemiology Case fatality rate Medicine and Health Sciences 030212 general & internal medicine Acute Respiratory Distress Syndrome Pathology and laboratory medicine Virus Testing Multidisciplinary Pharmaceutics Medical microbiology Middle Aged Hospitalization Cardiovascular Therapy Infectious Diseases Treatment Outcome Cardiovascular Diseases Viruses Medicine Female SARS CoV 2 Pathogens Research Article medicine.medical_specialty SARS coronavirus Science Cardiology Microbiology Respiratory Disorders 03 medical and health sciences Signs and Symptoms Drug Therapy Respiratory Failure Diagnostic Medicine medicine Humans Pandemics Aged Mechanical ventilation Biology and life sciences business.industry Organisms Viral pathogens COVID-19 Covid 19 medicine.disease Microbial pathogens Pneumonia Dyspnea Spain Clinical Medicine business |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 3, p e0248029 (2021) |
ISSN: | 1932-6203 |
Popis: | Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during spring followed by the current second wave in late summer and autumn. Empirical data show that the characteristics of the effects of the virus do vary between the two periods. Differences in age range and severity of the disease have been reported, although the comparative characteristics of the two waves still remain largely unknown. Those characteristics are compared in this study using data from two equal periods of 3 and a half months. The first period, between 15th March and 30th June, corresponding to the entire first wave, and the second, between 1st July and 15th October, corresponding to part of the second wave, still present at the time of writing this article. Two hundred and four patients were hospitalized during the first period, and 264 during the second period. Patients in the second wave were younger and the duration of hospitalization and case fatality rate were lower than those in the first wave. In the second wave, there were more children, and pregnant and post-partum women. The most frequent signs and symptoms in both waves were fever, dyspnea, pneumonia, and cough, and the most relevant comorbidities were cardiovascular diseases, type 2 diabetes mellitus, and chronic neurological diseases. Patients from the second wave more frequently presented renal and gastrointestinal symptoms, were more often treated with non-invasive mechanical ventilation and corticoids, and less often with invasive mechanical ventilation, conventional oxygen therapy and anticoagulants. Several differences in mortality risk factors were also observed. These results might help to understand the characteristics of the second wave and the behaviour and danger of SARS-CoV-2 in the Mediterranean area and in Western Europe. Further studies are needed to confirm our findings. |
Databáze: | OpenAIRE |
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