Prognostic and Survival-Related Factors in Patients with Well-Differentiated Oligodendrogliomas

Autor: de Divitiis E, Francesco Maiuri, Giorgio Iaconetta, C. Peca, M. Esposito, Del Basso De Caro Ml
Přispěvatelé: Maiuri, Francesco, DEL BASSO DE CARO, Marialaura, Iaconetta, Giorgio, Peca, Carmela, Esposito, M., DE DIVITIIS, Enrico, Iaconetta, G, Esposito, M, de Divitiis, E.
Rok vydání: 2006
Předmět:
Male
Oncology
Aging
Survival
analysis
medicine.medical_treatment
Cell
Neurosurgical Procedure
Neurosurgical Procedures
Antineoplastic Agent
chemistry.chemical_compound
Epidermal growth factor
Intercellular Signaling Peptides and Protein
Child
Tumor Markers
biology
Brain Neoplasms
Growth factor
Middle Aged
Prognosis
Combined Modality Therapy
Vascular endothelial growth factor
Treatment Outcome
medicine.anatomical_structure
Intercellular Signaling Peptides and Proteins
Female
Platelet-derived growth factor receptor
Human
Adult
medicine.medical_specialty
mortality/pathology/therapy
Adolescent
Prognosi
Oligodendroglioma
Antineoplastic Agents
Brain Neoplasm
Text mining
Antigen
Proliferating Cell Nuclear Antigen
Internal medicine
Biomarkers
Tumor
medicine
Humans
Tumor marker
Adolescent
Adult
Aged
Aging
Antineoplastic Agents
therapeutic use
Brain Neoplasms
mortality/pathology/therapy
Cell Proliferation
Child
Combined Modality Therapy
Female
Humans
Intercellular Signaling Peptides and Proteins
analysis
Ki-67 Antigen
analysis
Male
Middle Aged
Neurosurgical Procedures
Oligodendroglioma
mortality/pathology/therapy
Prognosis
Proliferating Cell Nuclear Antigen
analysis
Treatment Outcome
Tumor Markers
Biological
Aged
Cell Proliferation
business.industry
Proliferating cell nuclear antigen
Brain tumor
Ki-67 Antigen
chemistry
therapeutic use
biology.protein
Surgery
Neurology (clinical)
business
Zdroj: Zentralblatt für Neurochirurgie. 67:204-209
ISSN: 1438-9746
0044-4251
DOI: 10.1055/s-2006-942138
Popis: Oligodendrogliomas are brain tumors with unpredictable biological and clinical behavior. Prognostic factors related to survival are still controversial. The present study reviews 50 patients with well-differentiated (WHO grade II) oligodendrogliomas, located in the cerebral hemispheres and operated upon between 1980 and 1998. Prognostic factors studied include patient's age and sex, tumor location and extent, preoperative KPS, and extent of the surgical resection. The Ki-67 and the proliferative cell nuclear antigen (PCNA) levels were studied in all patients and some growth factors (GFs), including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and tenascine were examined in 20 patients. The long-term outcome and survival are not significantly correlated with the patient's age and sex, tumor location and extent, preoperative KPS and procedure for resection. Patients with lower Ki-67 and PCNA showed a significantly longer survival time (p < 0.001 and p < 0.019, respectively). Between 45 and 70 % of the tumors stained positive for one or more growth factors. Interestingly, cases with late recurrences (more than 4 years after surgery) and longer survival are significantly associated to negative GF expression or slight positivity, as compared with the variable and more often moderate immunoreactivity of cases with early anaplastic recurrences and shorter survival time. The presented data suggest that low proliferation indices and negative GF expression are associated with longer survival in well-differentiated oligodendrogliomas.
Databáze: OpenAIRE
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