| Autor: |
Xiao-Han Sun, Mei-Wei Lv, Ying-Xin Zhao, Hao Zhang, Muhammad Asmat Ullah Saleem, Yi Zhao, Jin-Long Li |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of agricultural and food chemistry. |
| ISSN: |
1520-5118 |
| Popis: |
Cadmium is a global ecological toxic pollutant; in animals, hepatotoxic fibrosis is caused by bioaccumulation of Cd through food chains. We determined the path of nano-Se antagonism in Cd-induced hepatocyte pyroptosis by targeting the APJ-AMPK-PGC1α pathway, using an in vivo model of hepatotoxicity. All 1-day-old chicks were treated with Cd (140 mg/kg BW/day) and/or nano-Se (0.3 or 0.6 mg/kg BW/day) for 90 days. The result showed that Cd (1.55 ± 0.148) activated NLRP3 inflammasome 49.903% as compared to the Con group (1.034 ± 0.008) to release the inflammasome as a result of hepatocyte pyroptosis (2.824 ± 0.057). Compared with the Con group (1.010 ± 0.021), Kupffer cells were 219.109% more to activate astrocytes through the APJ-AMPK-PGC1α pathway, resulting in 185.149% more hepatic fibrosis. However, the fibrosis degree of the H-Se + Cd group (1.252 ± 0.056) was 56.5278% ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
