Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma
| Autor: | Raffaella Ghislandi, Roberto Agazzi, Aurelio Sonzogni, Rocco Misiani, Sergio Pericotti, Marie-France Belair, Eugenio M. Poletti, Patrick Bruneval, Giambattista Cassinelli, Lucio Gualandris |
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| Rok vydání: | 1994 |
| Předmět: |
Leiomyosarcoma
medicine.medical_specialty Urology In situ hybridization Internal medicine Renin–angiotensin system Renin medicine Humans Retroperitoneal Neoplasms Enzyme Precursors Proteinuria business.industry Metabolic disorder Syndrome Middle Aged medicine.disease Angiotensin II Hypokalemia Endocrinology Nephrology Hypertension Female medicine.symptom Hyponatremia business |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 24(1) |
| ISSN: | 0272-6386 |
| Popis: | We report a case of renin-producing leiomyosarcoma associated with the hyponatremic hypertensive syndrome and nephrotic-range proteinuria. Extremely high levels of active renin and, to a greater extent, of prorenin were found in plasma and tumor tissue. Immunohistochemical and in situ hybridization studies demonstrated that the neoplastic cells were the source of renin production. The hyponatremic hypertensive syndrome and proteinuria promptly responded to treatment with angiotensin-converting enzyme inhibitors, suggesting an angiotensin II dependency of these disorders. After removal of the leiomyosarcoma, plasma concentration of active renin, but not of prorenin, normalized and the hypertension, proteinuria, and electrolyte abnormalities disappeared. However, 5 months after operation, the patient presented once again with hypertension, hypokalemia, proteinuria, and markedly increased plasma levels of both active renin and prorenin that heralded the relapse of neoplastic disease. |
| Databáze: | OpenAIRE |
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