Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma

Autor: Raffaella Ghislandi, Roberto Agazzi, Aurelio Sonzogni, Rocco Misiani, Sergio Pericotti, Marie-France Belair, Eugenio M. Poletti, Patrick Bruneval, Giambattista Cassinelli, Lucio Gualandris
Rok vydání: 1994
Předmět:
Zdroj: American journal of kidney diseases : the official journal of the National Kidney Foundation. 24(1)
ISSN: 0272-6386
Popis: We report a case of renin-producing leiomyosarcoma associated with the hyponatremic hypertensive syndrome and nephrotic-range proteinuria. Extremely high levels of active renin and, to a greater extent, of prorenin were found in plasma and tumor tissue. Immunohistochemical and in situ hybridization studies demonstrated that the neoplastic cells were the source of renin production. The hyponatremic hypertensive syndrome and proteinuria promptly responded to treatment with angiotensin-converting enzyme inhibitors, suggesting an angiotensin II dependency of these disorders. After removal of the leiomyosarcoma, plasma concentration of active renin, but not of prorenin, normalized and the hypertension, proteinuria, and electrolyte abnormalities disappeared. However, 5 months after operation, the patient presented once again with hypertension, hypokalemia, proteinuria, and markedly increased plasma levels of both active renin and prorenin that heralded the relapse of neoplastic disease.
Databáze: OpenAIRE