Acetazolamide with caffeine causes exencephaly in 'resistant' SWV mice
| Autor: | Charissa M. Urbano, Sidney L. Beck |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Litter Size Ratón Mice Inbred Strains Biology Exencephaly Toxicology chemistry.chemical_compound Mice Osteogenesis Pregnancy Internal medicine Caffeine medicine Animals Birth Weight Fetal Death Brain First cervical vertebra medicine.disease Embryo Mammalian Teratology Acetazolamide Endocrinology chemistry Toxicity Cervical Vertebrae Gestation Female medicine.drug |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 7(2) |
| ISSN: | 0890-6238 |
| Popis: | Pregnant SWV mice were treated on day 9 of gestation (PC) with 50 mg/kg of caffeine (CAFF), 200 mg/kg (LD) or 1000 mg/kg (HD) of acetazolamide (ACZM), or a combination of both agents, or on day 8 PC with both agents (ACZM + CAFF). Untreated (UNTD) and vehicle-treated (VEH) groups served as controls. The SWV strain is widely reported to be resistant to ACZM; it was resistant to ACZM or CAFF + ACZM when treated on day 9 of gestation, but a significant frequency of malformations, primarily exencephaly, was produced by ACZM + CAFF on day 8 PC. This study provides evidence that ACZM, coupled with a subteratogenic dose of caffeine can produce abnormalities in the "resistant" SWV mice, using the endpoint of exencephaly on day 8 of gestation. The mean number of ossified caudal vertebrae in day-9 treatments and ossified cervical vertebral centra in day-8 treatments were reduced. The frequency of ossification of the first cervical vertebra (C1) was reduced from 93% in UNTD to 39% in HD-ACZM day 9 PC and 69% in HD-ACZM + CAFF day 9 PC groups, and was also significantly reduced in the HD-ACZM + CAFF day-8 treated group. |
| Databáze: | OpenAIRE |
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