Development of Diabetes Mellitus Following Kidney Transplantation: A Canadian Experience
| Autor: | Fritz Diekmann, Sita Gourishankar, Gian S. Jhangri, Marcello Tonelli, Loreen H. Wales, Sandra M. Cockfield |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Graft Rejection Male Reoperation Canada medicine.medical_specialty Population Body Mass Index Postoperative Complications Internal medicine Diabetes mellitus Diabetes Mellitus Living Donors medicine Humans Immunology and Allergy Pharmacology (medical) education Intensive care medicine Survival analysis Kidney transplantation Aged Retrospective Studies Transplantation education.field_of_study business.industry Histocompatibility Testing Graft Survival Retrospective cohort study Middle Aged medicine.disease Kidney Transplantation Survival Analysis Tissue Donors Tacrolimus Calcineurin surgical procedures operative Cytomegalovirus Infections Trough level Female business Immunosuppressive Agents |
| Zdroj: | American Journal of Transplantation. 4:1876-1882 |
| ISSN: | 1600-6135 |
| Popis: | The onset of diabetes mellitus following kidney transplantation or post-transplant diabetes mellitus (PTDM) is now recognized as being an increasingly common complication that is associated with poor graft and patient survival. The incidence and clinical correlates of PTDM in a Canadian kidney transplant population has not been examined and may vary based on differences in demographics (i.e. race). Furthermore, little information exists on the association of variables such as cumulative dose of corticosteroids and trough calcineurin inhibitor levels and PTDM. We examined all recipients of a kidney transplant in our center between 1995 and 2001 and found an overall PTDM rate of 9.8%. Five clinical factors were independently associated with PTDM: older recipient age, deceased donor, hepatitis C antibody status, rejection episode and use of tacrolimus (vs. cyclosporine). Furthermore, cumulative corticosteroid dose and calcineurin inhibitor trough level were not associated with PTDM. This study demonstrates that in a Canadian kidney transplant population that there is a significant risk of PTDM following kidney transplantation, and it is therefore advisable to minimize this risk. |
| Databáze: | OpenAIRE |
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