Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery

Autor: Ece Özcan Bülbül, Neslihan Üstündağ Okur, Duygu Mısırlı, Erdal Cevher, Vasilios Tsanaktsis, Özlem Bingöl Özakpınar, Panoraia I. Siafaka
Přispěvatelé: Ozcan Bulbul E., Ustundag Okur N., Misirli D., Cevher E., Tsanaktsis V., BİNGÖL ÖZAKPINAR Ö., Siafaka P. I., İstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Ece Özcan Bülbül / 0000-0001-7112-923X, Özcan Bülbül, Ece, Ece Özcan Bülbül / FZS-1598-2022, Ece Özcan Bülbül / 57211920637
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Malzeme Bilimi (çeşitli)
MATERIALS SCIENCE
BIOMATERIALS
Polymers and Plastics
BIOAVAILABILITY
General Chemical Engineering
Kimya (çeşitli)
Temel Bilimler (SCI)
Physical Chemistry
MATERIALS SCIENCE
BLENDS
Kimya
Analytical Chemistry
paclitaxel
Polimerler ve Plastikler
Breast cancer
CHEMISTRY
NANOPARTICLES
General Materials Science
Temel Bilimler
CONTROLLED-RELEASE FORMULATIONS
Polimer Karakterizasyonu
Fizikokimya
POLİMER BİLİMİ
Chemistry (miscellaneous)
Natural Sciences (SCI)
Physical Sciences
Engineering and Technology
CRYSTALLIZATION
Natural Sciences
Characterization of Polymers
quality by design
Materials Science (miscellaneous)
POLYMER SCIENCE
film
FILMS
cancer treatment
Biomaterials
Engineering
Computing & Technology (ENG)
PLASTICIZERS
Mühendislik
Bilişim ve Teknoloji (ENG)
General Chemistry
IN-VITRO
Genel Kimya
lung cancer
Fizik Bilimleri
Biyomalzemeler
MALZEME BİLİMİ
BİYOMATERYAL
Genel Malzeme Bilimi
POLY(ETHYLENE SUCCINATE)
Mühendislik ve Teknoloji
SYSTEM
Malzeme Bilimi
Popis: In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) under the framework of quality by design, were blended to produce effective sustained-release matrices for Paclitaxel delivery. A complete physicochemical characterization including weight variation, thickness, water uptake, moisture absorption, moisture loss, and hydrolytic degradation under physiological conditions, was performed. Quality by design approach was applied to study the critical parameters. In vitro cancer toxicity was studied in human cancer cell lines including lung and breast adenocarcinoma. The developed Paclitaxel-loaded films can act as a promising alternative topical matrix as an implant for breast and lung cancer treatment. © 2022 Taylor & Francis Group, LLC. 2-s2.0-85130053009
Databáze: OpenAIRE
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