The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (HSP 90) reveals A 'DNA like' structure: Potential site of interaction with steroid receptors
| Autor: | Jean Garnier, Nadine Binart, Etienne-Emile Baulieu, Bruno Dumas, David Alun Rowlands, Maria-Grazia Catelli, Jonathan Levin, Béatrice Chambraud, Claire Bigogne |
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| Přispěvatelé: | Unité de biologie cellulaire et moléculaire, Institut National de la Recherche Agronomique (INRA), Communications hormonales (Inserm U33), Institut National de la Santé et de la Recherche Médicale (INSERM), Roussel-Uclaf, ProdInra, Migration |
| Rok vydání: | 1989 |
| Předmět: |
Glycosylation
STRUCTURE Protein Conformation [SDV]Life Sciences [q-bio] medicine.medical_treatment Molecular Sequence Data Biophysics Biology Molecular cloning Biochemistry Deoxyribonuclease EcoRI 03 medical and health sciences 0302 clinical medicine Sequence Homology Nucleic Acid Complementary DNA Heat shock protein medicine Animals Humans Amino Acid Sequence Cloning Molecular Phosphorylation Codon Receptor Molecular Biology Peptide sequence Protein secondary structure Heat-Shock Proteins ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Binding Sites Base Sequence Nucleic acid sequence Nucleic Acid Hybridization DNA Cell Biology [SDV] Life Sciences [q-bio] Molecular Weight Steroid hormone 030220 oncology & carcinogenesis Female Chickens Protein Kinases |
| Zdroj: | Biochemical and Biophysical Research Communications Biochemical and Biophysical Research Communications, Elsevier, 1989, 159, pp.140-147 Biochemical and Biophysical Research Communications, Elsevier, 1989, 159 (1), pp.140-147. ⟨10.1016/0006-291x(89)92415-7⟩ |
| ISSN: | 0006-291X 1090-2104 |
| DOI: | 10.1016/0006-291x(89)92415-7 |
| Popis: | International audience; We report cDNA sequence, the complete derived as sequence, and a predicted secondary structure of the chick hsp 90, a protein which has been found to form complexes with steroid hormone receptors. The modelling of the most negatively charged “region A” indicates that the α-helices of this portion of hsp 90 minick DNA configuration. We propose that this region can, in absence of hormone, interact with and cap the positively charged DNA-binding domain of steroid receptors. |
| Databáze: | OpenAIRE |
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