Responses of T cells from sensitized donors to recombinant and synthetic peptides corresponding to sequences of the Plasmodium falciparum SERP antigen
| Autor: | P. Dubois, M. Agrapart, B. Knapp, W. Stüber, J.J. Ballet, E. Hundt, Christian Roussilhon |
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| Rok vydání: | 1990 |
| Předmět: |
T-Lymphocytes
Molecular Sequence Data Plasmodium falciparum Immunology Protozoan Proteins Antigens Protozoan Peptide Biology Lymphocyte Activation Epitope law.invention Epitopes Antigen law Animals Humans Immunology and Allergy Amino Acid Sequence chemistry.chemical_classification T lymphocyte biology.organism_classification Virology Molecular biology Peptide Fragments Recombinant Proteins Amino acid chemistry Cell culture Recombinant DNA |
| Zdroj: | Immunology Letters. 25:149-153 |
| ISSN: | 0165-2478 |
| Popis: | In the present work, we intend to determine the capacity of human lymphocytes to recognize subfragments of the serine-stretch protein SERP, a bloodstage antigen from Plasmodium falciparum . Individuals sensitized by a previous P. falciparum infection were studied. Some recombinant proteins (RP) including RP7 and RP10 (amino acids 631–684 and 631–892 of SERP, respectively), were recognized in proliferation assays by lymphocytes from 28 sensitized individuals and not by lymphocytes from control, non-sensitized, donors. Synthetic peptides covering predefined zones of particular interest were tested and appeared to induce proliferative responses of lymphocytes from sensitized donors, allowing identification of putative T cell epitopes. |
| Databáze: | OpenAIRE |
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