Preserved renal perfusion during beta blockade by tertatolol with and without cyclooxygenase inhibition in normal humans
| Autor: | Marc Leeman, Jean-Paul Degaute, Jean-François Prost, Robert Naeije, Michel Abramowicz, Charles Reuse |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Urology Hemodynamics Renal function Blood Pressure Thiophenes Renal Circulation Propanolamines Random Allocation Double-Blind Method Heart Rate medicine Humans Pharmacology (medical) Cyclooxygenase Inhibitors Drug Interactions Cardiac Output Beta blocker Pharmacology Kidney Aspirin Renal circulation business.industry Perfusion medicine.anatomical_structure Tertatolol Anesthesia Renal blood flow business medicine.drug Glomerular Filtration Rate |
| Zdroj: | Journal of clinical pharmacology. 28(4) |
| ISSN: | 0091-2700 |
| Popis: | The systemic and renal hemodynamic effects of tertatolol, a new noncardioselective beta blocker without partial agonist activity, given alone or in combination with cyclooxygenase inhibition by acetylsalicylic acid (aspirin), were investigated in eight healthy volunteers. Tertatolol 5 mg, aspirin 1 g, tertatolol 5 mg together with aspirin 1 g and placebo were administered at 1-week intervals in a random order and in a double-blind fashion. Cardiac output was measured by Doppler echography and renal blood flow and glomerular filtration rate (GFR) by constant infusion techniques using (123I) iodohippurate and (51Cr) EDTA, respectively. Measurements were performed before and then successively 2 and 4 hours after oral intake of drugs or placebo. Tertatolol decreased cardiac output by 22% (P less than .05) and heart rate by 17% (P less than .05) without change in blood pressure, renal blood flow, and GFR. The same effects occurred when tertatolol was given together with aspirin. Either placebo or aspirin alone had no effect on systemic and renal hemodynamics. These results suggest that cardiac output is redistributed to the kidneys after tertatolol intake in normal humans. This favorable effect on renal hemodynamics is probably not mediated by a local release of vasodilating prostaglandins. |
| Databáze: | OpenAIRE |
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