Rhesus Rotavirus Trafficking during Entry into MA104 Cells Is Restricted to the Early Endosome Compartment
| Autor: | Marie Wolf, Emily M. Deal, Harry B. Greenberg |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Rotavirus
Endosome Immunology Mutant Endosomes Biology Endocytosis medicine.disease_cause Microbiology Rotavirus Infections Cell Line Viral Proteins Virology medicine Animals Late endosome rab5 GTP-Binding Proteins Infectivity Compartment (ship) fungi Primate Diseases Virus Internalization Macaca mulatta Virus-Cell Interactions Cell biology Cell culture Insect Science biological phenomena cell phenomena and immunity |
| Zdroj: | Journal of Virology. 86:4009-4013 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Endocytosis has recently been implicated in rotavirus (RV) entry. We examined the role of Rabs, which regulate endosomal trafficking, during RV entry. Several structural proteins of neuraminidase-sensitive and -insensitive RVs colocalized with Rab5, an early endosome marker, but not Rab7, a late endosome marker. Dominant-negative and constitutively active mutants demonstrated that Rab5 but not Rab4 or Rab7 affects rhesus RV (RRV) infectivity. These data suggest that early RRV trafficking is confined to the early endosome compartment and requires Rab5. |
| Databáze: | OpenAIRE |
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