Colitis induced by sodium polystyrene sulfonate in sorbitol: A report of six cases
| Autor: | Ashok Parameswaran, Sheba Sk Jacob, Sarojini Ashok Parameswaran, Ubal Dhus |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Hyperkalemia Colon medicine.medical_treatment Laxative Administration Oral Enema Gastroenterology Diagnosis Differential 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Intestinal mucosa Internal medicine medicine Humans Sorbitol 030212 general & internal medicine Intestinal Mucosa Colitis Aged business.industry Middle Aged medicine.disease Uremia Surgery Drug Combinations chemistry Laxatives 030220 oncology & carcinogenesis Polystyrenes Female medicine.symptom business Sodium Polystyrene Sulfonate |
| Zdroj: | Indian Journal of Gastroenterology. 35:139-142 |
| ISSN: | 0975-0711 0254-8860 |
| DOI: | 10.1007/s12664-016-0635-2 |
| Popis: | Drug-related injury has been noted in virtually all organ systems, and recognition of the patterns of injury associated with medication enables modification of treatment and reduces the morbidity associated with the side effects of drugs. With the large number of new drugs being developed, documentation of the morphology of the changes seen as an adverse effect becomes important to characterize the pattern of injury. The pathologist is often the first to identify these abnormalities and correlate them with a particular drug. Kayexalate or sodium polystyrene sulfonate (SPS), a linear polymer derived from polystyrene containing sulfonic acid and sulfonate functional groups is used to treat hyperkalemia. It is usually administered with an osmotic laxative sorbitol orally or as retention enema. This combination has been implicated in causing damage to different parts of the gastrointestinal (GI) tract especially the colon and causes an established pattern of injury, recognizable by the presence of characteristic crystals, is presented to create a greater awareness of the Kayexalate colitis. This entity should be included in the differential diagnosis of lower GI mucosal injury in a setting of uremia and hyperkalemia. |
| Databáze: | OpenAIRE |
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