Information processing deficits as a driving force for memory impairment in MS: A cross-sectional study of memory functions and MRI in early and late stage MS
| Autor: | Martin R. Fischer, Peter Bublak, Frank Hoffmann, Jürgen H. Faiss, Michael Sailer, Annett Kunkel, Matthias Schwab, Erhard Stadler, Uwe K. Zettl, Wolfgang Köhler, Iris-Katharina Penner |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Hippocampus Neuropsychological Tests Hippocampal formation Audiology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Memory Encoding (memory) Humans Medicine Memory impairment Memory functions Memory Disorders business.industry Neuropsychology Brain Organ Size General Medicine Middle Aged Magnetic Resonance Imaging Cross-Sectional Studies Free recall Neurology Brain size Disease Progression Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis and Related Disorders. 18:119-127 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2017.09.026 |
| Popis: | Background Memory impairment (MI) is a common symptom of MS. Previous studies were conflicting in respect to the possible existence of early MI and the role of hippocampal atrophy. The objective of this study was to investigate MI and structural MRI correlates in homogenous groups of early and late MS, controlling for a potential information-processing speed (IPS) deficit, and utilizing multiple memory test paradigms. Methods 152 individually matched subjects were recruited: early MS (EMS, N = 25, disease duration 1.0 ± 0.8 years), late MS (LMS, N = 52, 16.5 ± 5.2 years), and corresponding controls. Five memory tests were utilized to account for differences in learning material (verbal, visual), encoding (incidental, intentional), and retrieval (free recall, recognition, recurring recognition). Performance was related to IPS, memory-specific (hippocampal volumes), and unspecific MRI measures (T1/T2LL, brain volume, cortical thickness). Results Memory was impaired across all tests in LMS, but not in EMS. LMS-patients were also significantly impaired in IPS which was correlated with several memory scores. Regression analyses revealed IPS and cortical thickness as predictors for visual MI, and IPS, sex, and left hippocampal volume as predictors for verbal MI. Conclusion Additionally to direct destructions in memory specific tracts such as the hippocampus, memory decline in MS may also be related to a general factor comprising slowed information-processing and global tissue loss. |
| Databáze: | OpenAIRE |
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