Androgen receptor expression in male breast cancer predicts inferior outcome and poor response to tamoxifen treatment
| Autor: | Tang Dabei, Wang Zhipeng, Song Hongtao, Zhang Qingyuan, Geng Jingshu, Zhong Lei, Piao Ying, He Xiaohui, Li Shuo, Zhao Wenhui |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Antineoplastic Agents Hormonal Receptor ErbB-2 Endocrinology Diabetes and Metabolism Kaplan-Meier Estimate Disease-Free Survival Breast Neoplasms Male Endocrinology Breast cancer Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Humans skin and connective tissue diseases Lymph node Aged Neoplasm Staging Proportional hazards model business.industry Estrogen Antagonists Cancer General Medicine Sex hormone receptor Middle Aged medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Androgen receptor Tamoxifen Ki-67 Antigen Treatment Outcome medicine.anatomical_structure Receptors Estrogen Chemotherapy Adjuvant Receptors Androgen Male breast cancer Receptors Progesterone business |
| Zdroj: | European Journal of Endocrinology. 171:527-533 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveAndrogen receptor (AR) plays an important role in male breast cancer (MBC). Additionally, endocrine therapy is the most important treatment in oestrogen receptor (ER)-positive advanced breast cancer. This study was aimed to investigate the role of AR in MBC treatment and prognosis and to analyse the relationship between AR and the effect of tamoxifen treatment in MBC patients.MethodsAR protein levels and other tumour characteristics (e.g. expression of ER (ESR1), PR (PGR), AR, HER2 (ERBB2) and Ki-67 (MKI67)) in breast cancer tissue from 102 MBC patients were determined using immunohistochemical analysis. Additionally, the relationship between AR status and clinicopathological features was analysed using the χ2-test. Association with survival was initially analysed using the Kaplan–Meier method and the log-rank test, and Cox regression analysis was used to adjust for other prognostic indicators.ResultsHigh expression of AR was not correlated with T-stage, histological grade, HER2 status and the status of other sex hormone receptors, but was associated with lymph node metastases (P=0.032). AR-positive patients showed significantly shorter 5-year overall survival (OS) rates (P=0.045) and 5-year disease-free survival (DFS) rates (P=0.026) than AR-negative patients. By contrast, for patients who received tamoxifen therapy, AR-negative patients showed a higher clinical benefit rate than AR-positive patients (P=0.025). Additionally, the median TTP and OS were significantly different (P=0.02 for TTP; P=0.029 for OS).ConclusionsAR expression correlates strongly with both OS and DFS in patients with MBC. AR-positive patients can predict a poorer clinical outcome than AR-negative patients after adjuvant tamoxifen therapy. |
| Databáze: | OpenAIRE |
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